An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket
dc.contributor.author
Debler, Erik W.
dc.contributor.author
Müller, Roger
dc.contributor.author
Hilvert, Donald
dc.contributor.author
Wilson, Ian A.
dc.date.accessioned
2017-06-08T23:32:21Z
dc.date.available
2017-06-08T23:32:21Z
dc.date.issued
2009
dc.identifier.issn
0027-8424
dc.identifier.issn
1091-6490
dc.identifier.other
10.1073/pnas.0902700106
dc.identifier.uri
http://hdl.handle.net/20.500.11850/19416
dc.language.iso
en
dc.publisher
National Academy of Sciences
dc.subject
catalytic antibody
dc.subject
crystal structure
dc.subject
enzyme design
dc.subject
enzyme mechanism
dc.subject
proton transfer
dc.title
An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket
dc.type
Journal Article
ethz.journal.title
Proceedings of the National Academy of Sciences of the United States of America
ethz.journal.volume
106
ethz.journal.issue
44
ethz.journal.abbreviated
Proc Natl Acad Sci U S A
ethz.pages.start
18539
ethz.pages.end
18544
ethz.notes
Approved September 11 2009, Received for review March 11 2009.
ethz.identifier.wos
ethz.identifier.nebis
001003347
ethz.publication.place
Washington, D.C.
ethz.publication.status
published
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02514 - Laboratorium für Organische Chemie / Laboratory of Organic Chemistry::03492 - Hilvert, Donald (emeritus) / Hilvert, Donald (emeritus)
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02514 - Laboratorium für Organische Chemie / Laboratory of Organic Chemistry::03492 - Hilvert, Donald (emeritus) / Hilvert, Donald (emeritus)
ethz.date.deposited
2017-06-08T23:32:28Z
ethz.source
ECIT
ethz.identifier.importid
imp59364ca49447e79513
ethz.ecitpid
pub:31759
ethz.eth
yes
ethz.availability
Metadata only
ethz.rosetta.installDate
2017-07-18T17:36:47Z
ethz.rosetta.lastUpdated
2022-03-28T08:40:16Z
ethz.rosetta.versionExported
true
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Journal Article [122036]