Differential interactions between Notch and ID factors control neurogenesis by modulating Hes factor autoregulation

Open access
Date
2017-10-03Type
- Journal Article
Citations
Cited 33 times in
Web of Science
Cited 31 times in
Scopus
ETH Bibliography
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Abstract
During embryonic and adult neurogenesis, neural stem cells (NSCs)
generate the correct number and types of neurons in a temporospatial
fashion. Control of NSC activity and fate is crucial for brain formation
and homeostasis. Neurogenesis in the embryonic and adult brain
differ considerably, but Notch signaling and inhibitor of DNA-binding
(ID) factors are pivotal in both. Notch and ID factors regulate NSC
maintenance; however, it has been difficult to evaluate how these
pathways potentially interact. Here, we combined mathematical
modeling with analysis of single-cell transcriptomic data to elucidate
unforeseen interactions between the Notch and ID factor pathways.
During brain development, Notch signaling dominates and directly
regulates Id4 expression, preventing other ID factors from inducing
NSC quiescence. Conversely, during adult neurogenesis, Notch
signaling and Id2/3 regulate neurogenesis in a complementary
manner and ID factors can induce NSC maintenance and
quiescence in the absence of Notch. Our analyses unveil key
molecular interactions underlying NSC maintenance and mechanistic
differences between embryonic and adult neurogenesis. Similar Notch
and ID factor interactions may be crucial in other stem cell systems. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000195780Publication status
publishedExternal links
Journal / series
DevelopmentVolume
Pages / Article No.
Publisher
Company of BiologistsSubject
Notch signaling; Id transcription factors; Neural stem cells; Neurogenesis; Computational biologyOrganisational unit
03791 - Iber, Dagmar / Iber, Dagmar
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Show all metadata
Citations
Cited 33 times in
Web of Science
Cited 31 times in
Scopus
ETH Bibliography
yes
Altmetrics