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  1. The Major RNA-Binding Protein ProQ Impacts Virulence Gene Expression in Salmonella enterica Serovar Typhimurium 

    Westermann, Alexander J.; Venturini, Elisa; Sellin, Mikael E.; et al. (2019)
    FinO domain proteins such as ProQ of the model pathogen Salmonella enterica have emerged as a new class of major RNA-binding proteins in bacteria. ProQ has been shown to target hundreds of transcripts, including mRNAs from many virulence regions, but its role, if any, in bacterial pathogenesis has not been studied. Here, using a Dual RNA-seq approach to profile ProQ-dependent gene expression changes as Salmonella infects human cells, we ...
    Journal Article
  2. Sensitivity Analysis of the Eisenberg - Noe clearing vector to individual interbank liabilities 

    Schaanning, Eric Finn; Feinstein, Zachary; Rudloff, Birgit; et al. (2018)
    SIAM Journal on Financial Mathematics
    We quantify the sensitivity of the Eisenberg--Noe clearing vector to estimation errors in the bilateral liabilities of a financial system. The interbank liabilities matrix is a crucial input to the computation of the clearing vector. However, in practice central bankers and regulators must often estimate this matrix because complete information on bilateral liabilities is rarely available. As a result, the clearing vector may suffer from ...
    Journal Article
  3. Genome Mining-guided and MALDI Imaging-assisted Discovery of New Antibiotics 

    Probst, Silke I.; Vogel, Christine; Vorholt, Julia A.; et al. (2018)
    CHIMIA International Journal for Chemistry
    Journal Article
  4. Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback 

    Menshykau, Denis; Michos, Odyssé; Lang, Christine; et al. (2019)
    Nature Communications
    Branching patterns and regulatory networks differ between branched organs. It has remainedunclear whether a common regulatory mechanism exists and how organ-specific patterns canemerge. Of all previously proposed signalling-based mechanisms, only a ligand-receptor-based Turing mechanism based on FGF10 and SHH quantitatively recapitulates the lungbranching patterns. We now show that a GDNF-dependent ligand-receptor-based Turingmechanism ...
    Journal Article
  5. BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2 

    Cline, Melissa S. AND Liao, Rachel G. AND Parsons, Michael T. AND Paten, Benedict AND Alquaddoomi, Faisal AND Antoniou, Antonis AND Baxter, Samantha AND Brody, Larry AND Cook-Deegan, Robert AND Coffin, Amy AND Couch, Fergus J. AND Craft, Brian AND Currie, Robert AND Dlott, Chloe C. AND Dolman, Lena AND den Dunnen, Johan T. AND Dyke, Stephanie O. M. AND Domchek, Susan M. AND Easton, Douglas AND Fischmann, Zachary AND Foulkes, William D. AND Garber, Judy AND Goldgar, David AND Goldman, Mary J. AND Goodhand, Peter AND Harrison, Steven AND Haussler, David AND Kato, Kazuto AND Knoppers, Bartha AND Markello, Charles AND Nussbaum, Robert AND Offit, Kenneth AND Plon, Sharon E. AND Rashbass, Jem AND Rehm, Heidi L. AND Robson, Mark AND Rubinstein, Wendy S. AND Stoppa-Lyonnet, Dominique AND Tavtigian, Sean AND Thorogood, Adrian AND Zhang, Can AND Zimmermann, Marc AND BRCA Challenge Authors AND Burn, John AND Chanock, Stephen AND Rätsch, Gunnar AND Spurdle, Amanda B. (2018)
    PLOS Genetics
    Author summary The goal of this study and paper has been to develop an international resource to generate an informed and current understanding of the impact of genetic variation on cancer risk across the cancer predisposition genes, BRCA1 and BRCA2. Reported variants in BRCA1 and BRCA2 available from public databases were integrated into a single, newly created site, www.brcaexchange.org, to provide a reliable and easily accessible record ...
    Journal Article
  6. Improving Clinical Predictions through Unsupervised Time Series Representation Learning 

    Lyu, Xinrui; Hueser, Matthias; Hyland, Stephanie L. and Zerveas, George; et al. (2018)
    arXiv e-prints
    Journal Article
  7. Scalable Gaussian Processes on Discrete Domains 

    Fortuin, Vincent; Dresdner, Gideon; Strathmann, Heiko and Rätsch, Gunnar (2018)
    arXiv e-prints
    Journal Article
  8. Biological processes dominate phosphorus dynamics under low phosphorus availability in organic horizons of temperate forest soils 

    Pistocchi, Chiara; Mészáros, Eva; Frossard, Emmanuel; et al. (2018)
    Soil biology and biochemistry
    Journal Article
  9. Observation of quadrupole transitions and edge mode topology in an LC circuit network 

    Serra-Garcia, Marc; Süsstrunk, Roman; Huber, Sebastian D. (2019)
    Physical Review B
    Journal Article
  10. SOM-VAE: Interpretable Discrete Representation Learning on Time Series 

    Fortuin, Vincent; Hüser, Matthias; Locatello, Francesco and Strathmann, Heiko; et al. (2018)
    arXiv e-prints
    Journal Article
  11. EIF1AX and RAS mutations cooperate to drive thyroid tumorigenesis through ATF4 and c-MYC 

    Krishnamoorthy, Gnana P.; Davidson, Natalie R; Leach, Steven D; et al. (2018)
    Cancer Discovery
    Translation initiation is orchestrated by the cap binding and 43S pre-initiation complexes (PIC). Eukaryotic initiation factor 1A (EIF1A) is essential for recruitment of the ternary complex and for assembling the 43S PIC. Recurrent EIF1AX mutations in papillary thyroid cancers are mutually exclusive with other drivers, including RAS. EIF1AX is enriched in advanced thyroid cancers, where it displays a striking co-occurrence with RAS, which ...
    Journal Article
  12. Genomic basis for RNA alterations revealed by whole-genome analyses of 27 cancer types 

    ,; Calabrese, Claudia; Davidson, Natalie R; et al. (2018)
    We present the most comprehensive catalogue of cancer-associated gene alterations through characterization of tumor transcriptomes from 1,188 donors of the Pan-Cancer Analysis of Whole Genomes project. Using matched whole-genome sequencing data, we attributed RNA alterations to germline and somatic DNA alterations, revealing likely genetic mechanisms. We identified 444 associations of gene expression with somatic non-coding single-nucleotide ...
    Journal Article
  13. New ethical challenges of digital technologies, machine learning and artificial intelligence in public health: a call for papers 

    Zandi, Diana; Reis, Andreas; Vayena, Effy; et al. (2019)
    Bulletin of the World Health Organization
    Journal Article
  14. Piezoelectrically Enhanced Photocatalysis with BiFeO 3 Nanostructures for Efficient Water Remediation 

    Mushtaq, Fajer; Chen, Xiangzhong; Hoop, Marcus; et al. (2018)
    Journal Article
  15. Dynamic mean-variance optimisation problems with deterministic information 

    Schweizer, Martin; Zivoi, Danijel; Šikić, Mario (2018)
    International Journal of Theoretical and Applied Finance
    Journal Article
  16. Charging Drivers by the Pound: How Does the UK Vehicle Tax System Affect CO2 Emissions? 

    Cerruti, Davide; Alberini, Anna; Linn, Joshua (2019)
    Environmental and Resource Economics
    Journal Article
  17. Large-Scale Neuromorphic Spiking Array Processors: A Quest to Mimic the Brain (vol 12, 891, 2018) 

    Thakur, Chetan Singh; Molin, Jamal Lottier; Cauwenberghs, Gert; et al. (2019)
    Other Journal Item
  18. BAT AGN Spectroscopic Survey. XI. The Covering Factor of Dust and Gas in Swift/BAT Active Galactic Nuclei 

    Ichikawa, Kohei; Ricci, Claudio; Ueda, Yoshihiro; et al. (2019)
    Journal Article
  19. Efficient and Equitable Policy Design: Taxing Energy Use or Promoting Energy Savings? 

    Landis, Florian; Rausch, Sebastian; Kosch, Mirjam; et al. (2019)
    Journal Article
  20. Activation of Primary and Secondary Benzylic and Tertiary Alkyl (sp(3))C-F Bonds Inside a Self-Assembled Molecular Container 

    Koster, Jesper M.; Haussinger, Daniel; Tiefenbacher, Konrad (2019)
    Journal Article

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