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dc.contributor.author
Montagne, Jacques
dc.contributor.author
Lecerf, Caroline
dc.contributor.author
Parvy, Jean-Philippe
dc.contributor.author
Bennion, Janis M.
dc.contributor.author
Radimerski, Thomas
dc.contributor.author
Ruhf, Marie-Laure
dc.contributor.author
Zilbermann, Frederic
dc.contributor.author
Vouilloz, Nicole
dc.contributor.author
Stocker, Hugo
dc.contributor.author
Hafen, Ernst
dc.contributor.author
Kozma, Sara C.
dc.contributor.author
Thomas, George
dc.date.accessioned
2018-10-30T17:56:51Z
dc.date.available
2017-06-08T23:54:31Z
dc.date.available
2018-10-30T17:56:51Z
dc.date.issued
2010-05-06
dc.identifier.issn
1553-7390
dc.identifier.issn
1553-7404
dc.identifier.other
10.1371/journal.pgen.1000937
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/20460
dc.identifier.doi
10.3929/ethz-b-000020460
dc.description.abstract
S6 kinases (S6Ks) act to integrate nutrient and insulin signaling pathways and, as such, function as positive effectors in cell growth and organismal development. However, they also have been shown to play a key role in limiting insulin signaling and in mediating the autophagic response. To identify novel regulators of S6K signaling, we have used a Drosophila-based, sensitized, gain-of-function genetic screen. Unexpectedly, one of the strongest enhancers to emerge from this screen was the nuclear receptor (NR), Drosophila hormone receptor 3 (DHR3), a critical constituent in the coordination of Drosophila metamorphosis. Here we demonstrate that DHR3, through dS6K, also acts to regulate cell-autonomous growth. Moreover, we show that the ligand-binding domain (LBD) of DHR3 is essential for mediating this response. Consistent with these findings, we have identified an endogenous DHR3 isoform that lacks the DBD. These results provide the first molecular link between the dS6K pathway, critical in controlling nutrient-dependent growth, and that of DHR3, a major mediator of ecdysone signaling, which, acting together, coordinate metamorphosis.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science (PLoS)
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
The Nuclear Receptor DHR3 Modulates dS6 Kinase-Dependent Growth in Drosophila
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
PLoS Genetics
ethz.journal.volume
6
en_US
ethz.journal.issue
5
en_US
ethz.journal.abbreviated
PLoS Genet
ethz.pages.start
e1000937
en_US
ethz.size
12 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
005410305
ethz.publication.place
San Francisco, CA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03710 - Hafen, Ernst / Hafen, Ernst
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03710 - Hafen, Ernst / Hafen, Ernst
ethz.date.deposited
2017-06-08T23:54:39Z
ethz.source
ECIT
ethz.identifier.importid
imp59364cb89963157550
ethz.ecitpid
pub:32954
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-12T12:04:19Z
ethz.rosetta.lastUpdated
2018-10-30T17:57:14Z
ethz.rosetta.versionExported
true
ethz.COinS
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