Yeast Creates a Niche for Symbiotic Lactic Acid Bacteria through Nitrogen Overflow
Sévin, Daniel C.
Patil, Kiran Raosaheb
- Journal Article
Rights / licenseCreative Commons Attribution 4.0 International
Many microorganisms live in communities and depend on metabolites secreted by fellow community members for survival. Yet our knowledge of interspecies metabolic dependencies is limited to few communities with small number of exchanged metabolites, and even less is known about cellular regulation facilitating metabolic exchange. Here we show how yeast enables growth of lactic acid bacteria through endogenous, multi-component, crossfeeding in a readily established community. In nitrogen- rich environments, Saccharomyces cerevisiae adjusts its metabolism by secreting a pool of metabolites, especially amino acids, and thereby enables survival of Lactobacillus plantarum and Lactococcus lactis. Quantity of the available nitrogen sources and the status of nitrogen catabolite repression pathways jointly modulate this niche creation. We demonstrate how nitrogen overflow by yeast benefits L. plantarum in grape juice, and contributes to emergence of mutualism with L. lactis in a medium with lactose. Our results illustrate how metabolic decisions of an individual species can benefit others Show more
Journal / seriesCell Systems
Pages / Article No.
Organisational unit03713 - Sauer, Uwe / Sauer, Uwe
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