Development of a Phase-Contrast Clinical Mammography Prototype for the In-Vivo Investigation of Breast Cancer
Arboleda Clavijo, Carolina
- Doctoral Thesis
Rights / licenseIn Copyright - Non-Commercial Use Permitted
Breast cancer is the second leading cause of cancer death in women. Its detection in early stages increases the survival rate and thus contributes to the life quality of the patient. Currently, attenuation-based mammography is the most utilized screening technique. However, it is not capable of detecting some important malignant formations, due to small di erences in X-ray attenuation between them and healthy tissue. Phase contrast X-ray imaging has demonstrated to improve soft tissue contrast and, therefore, has proven to be useful for breast cancer detection. However, it generally demands the use of highly-coherent sources, like synchrotrons, which are di cult to access and therefore transfer to the clinical environment. The advent of X-ray grating interferometry has paved the way for the transfer of the phase-contrast technology to the clinics, since it can be performed with a regular X-ray tube. Although there have been several investigative works on gratingbased phase-contrast mammography, none of them has really managed to address all the issues that imply the commissioning of such a technique in a hospital, like the minimum required eld-of-view, maximum allowed exposure time, dose limitation and geometrical constraints. This thesis presents the design, development and succesful implementation of a fully clinically-compatible X-ray grating-based mammography prototype. In addition, it summarizes the outcomes of an exhaustive investigation of the scattering properties of breast microcalci cations from the micrometer to the nanometer range and how they can be exploited to non-invasively diagnose malignant breast lesions Show more
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ContributorsSupervisor: Stampanoni, Marco
Supervisor: Kubik-Huch, Rahel A.
Supervisor: Pelc, Norbert
Supervisor: Koehler, Thomas
SubjectX-ray grating interferometry; Phase-contrast imaging; Mammography; Breast cancer; Small-angle and wide-angle X-ray scattering; Ptychography
Organisational unit03817 - Stampanoni, Marco F.M.
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