Dang, Thanh Quy
Seebeck, Florian P.
- Journal Article
Formylglycine-generating enzyme (FGE) is an O2-utilizing oxidase that converts specific cysteine residues of client proteins to formylglycine. We show that CuI is an integral cofactor of this enzyme and binds with high affinity (KD=of 10−17 m) to a pair of active-site cysteines. These findings establish FGE as a novel type of copper enzyme Show more
Journal / seriesChemBioChem
SubjectCopper; EPR; Formylglycine; Oxidases; Oxygen activation; Protein engineering
Organisational unit03810 - Jeschke, Gunnar
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