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dc.contributor.author
Wagner, Konstanze M.
dc.contributor.author
Rüegg, Marcel
dc.contributor.author
Niemann, Axel
dc.contributor.author
Suter, Ueli
dc.date.accessioned
2018-07-12T09:12:39Z
dc.date.available
2017-06-09T00:05:31Z
dc.date.available
2018-07-12T09:12:39Z
dc.date.issued
2009
dc.identifier.issn
1932-6203
dc.identifier.other
10.1371/journal.pone.0005160
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/20991
dc.identifier.doi
10.3929/ethz-b-000020991
dc.description.abstract
Proteins controlling mitochondrial dynamics are often targeted to and anchored into the mitochondrial outer membrane (MOM) by their carboxyl-terminal tail-anchor domain (TA). However, it is not known whether the TA modulates protein function. GDAP1 is a mitochondrial fission factor with two neighboring hydrophobic domains each flanked by basic amino acids (aa). Here we define GDAP1 as TA MOM protein. GDAP1 carries a single transmembrane domain (TMD) that is, together with the adjacent basic aa, critical for MOM targeting. The flanking N-terminal region containing the other hydrophobic domain is located in the cytoplasm. TMD sequence, length, and high hydrophobicity do not influence GDAP1 fission function if MOM targeting is maintained. The basic aa bordering the TMD in the cytoplasm, however, are required for both targeting of GDAP1 as part of the TA and GDAP1-mediated fission. Thus, this GDAP1 region contains critical overlapping motifs defining intracellular targeting by the TA concomitant with functional aspects.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.title
Targeting and function of the mitochondrial fission factor GDAP1 are dependent on Its tail-anchor
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 3.0 Unported
dc.date.published
2009-04-02
ethz.journal.title
PLoS ONE
ethz.journal.volume
4
en_US
ethz.journal.issue
4
en_US
ethz.journal.abbreviated
PLoS ONE
ethz.pages.start
e5160
en_US
ethz.size
11 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
San Francisco, CA
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-09T00:05:53Z
ethz.source
ECIT
ethz.identifier.importid
imp59364cc31b6d826648
ethz.ecitpid
pub:33612
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-12T20:08:13Z
ethz.rosetta.lastUpdated
2018-09-01T10:30:46Z
ethz.rosetta.versionExported
true
ethz.COinS
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