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dc.contributor.author
Pinkett, Heather W.
dc.contributor.author
Lee, Allen T.
dc.contributor.author
Lum, P.
dc.contributor.author
Locher, Kaspar P.
dc.contributor.author
Rees, Douglas C.
dc.date.accessioned
2021-03-01T07:52:18Z
dc.date.available
2017-06-08T15:43:54Z
dc.date.available
2021-03-01T07:52:18Z
dc.date.issued
2007-01-19
dc.identifier.issn
0036-8075
dc.identifier.issn
1095-9203
dc.identifier.other
10.1126/science.1133488
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/2143
dc.description.abstract
The crystal structure of a putative metal-chelate–type adenosine triphosphate (ATP)–binding cassette (ABC) transporter encoded by genes HI1470 and HI1471 of Haemophilus influenzae has been solved at 2.4 angstrom resolution. The permeation pathway exhibits an inward-facing conformation, in contrast to the outward-facing state previously observed for the homologous vitamin B12 importer BtuCD. Although the structures of both HI1470/1 and BtuCD have been solved in nucleotide-free states, the pairs of ABC subunits in these two structures differ by a translational shift in the plane of the membrane that coincides with a repositioning of the membrane-spanning subunits. The differences observed between these ABC transporters involve relatively modest rearrangements and may serve as structural models for inward- and outward-facing conformations relevant to the alternating access mechanism of substrate translocation.
en_US
dc.language.iso
en
en_US
dc.publisher
Science
en_US
dc.title
An inward-facing conformation of a putative metal-chelate-type ABC transporter
en_US
dc.type
Journal Article
dc.date.published
2006-12-07
ethz.journal.title
Science
ethz.journal.volume
315
en_US
ethz.journal.issue
5810
en_US
ethz.pages.start
373
en_US
ethz.pages.end
377
en_US
ethz.identifier.wos
ethz.identifier.nebis
000012517
ethz.publication.place
Cambridge, MA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02521 - Inst. f. Molekularbiologie u. Biophysik / Inst. Molecular Biology and Biophysics::03652 - Locher, Kaspar / Locher, Kaspar
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02521 - Inst. f. Molekularbiologie u. Biophysik / Inst. Molecular Biology and Biophysics::03652 - Locher, Kaspar / Locher, Kaspar
ethz.date.deposited
2017-06-08T15:44:03Z
ethz.source
ECIT
ethz.identifier.importid
imp59364b4c7bc7958737
ethz.ecitpid
pub:12026
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2017-07-12T14:00:24Z
ethz.rosetta.lastUpdated
2020-02-14T04:15:11Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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