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dc.contributor.author
Allen, Richard C.
dc.contributor.author
Engelstädter, Jan
dc.contributor.author
Bonhoeffer, Sebastian
dc.contributor.author
McDonald, Bruce A.
dc.contributor.author
Hall, Alex
dc.date.accessioned
2017-12-01T06:44:41Z
dc.date.available
2017-10-17T12:51:16Z
dc.date.available
2017-10-17T13:24:34Z
dc.date.available
2017-11-30T15:11:58Z
dc.date.available
2017-12-01T06:44:41Z
dc.date.issued
2017-09-27
dc.identifier.issn
0962-8452
dc.identifier.issn
1471-2954
dc.identifier.other
10.1098/rspb.2017.1619
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/216140
dc.identifier.doi
10.3929/ethz-b-000196595
dc.description.abstract
Resistance spreads rapidly in pathogen or pest populations exposed to bio- cides, such as fungicides and antibiotics, and in many cases new biocides are in short supply. How can resistance be reversed in order to prolong the effec- tiveness of available treatments? Some key parameters affecting reversion of resistance are well known, such as the fitness cost of resistance. However, the population biological processes that actually cause resistance to persist or decline remain poorly characterized, and consequently our ability to manage reversion of resistance is limited. Where do susceptible genotypes that replace resistant lineages come from? What is the epidemiological scale of reversion? What information do we need to predict the mechanisms or likelihood of reversion? Here, we define some of the population biological processes that can drive reversion, using examples from a wide range of taxa and biocides. These processes differ primarily in the origin of revertant genotypes, but also in their sensitivity to factors such as coselection and compensatory evolution that can alter the rate of reversion, and the likelihood that resistance will re-emerge upon re-exposure to biocides. We therefore argue that discriminating among different types of reversion allows for better prediction of where resistance is most likely to persist.
en_US
dc.format
application/pdf
dc.language.iso
en
en_US
dc.publisher
The Royal Society
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Reversing resistance
en_US
dc.subject
Biocides
en_US
dc.subject
Antimicrobials
en_US
dc.subject
Fungicides
en_US
dc.title
Reversing resistance: different routes and common themes across pathogens
en_US
dc.type
Review Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2017-09-27
ethz.journal.title
Proceedings of the Royal Society. B, Biological Sciences
ethz.journal.volume
284
en_US
ethz.journal.issue
1863
en_US
ethz.journal.abbreviated
Proc R Soc Lond B Biol Sci
ethz.pages.start
20171619
en_US
ethz.size
10 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.code.ddc
DDC - DDC::5 - Science::570 - Life sciences
en_US
ethz.grant
The role of bacteria-virus interactions in antimicrobial resistance
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::09497 - Hall, Alex / Hall, Alex
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03516 - McDonald, Bruce / McDonald, Bruce
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03584 - Bonhoeffer, Sebastian / Bonhoeffer, Sebastian
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::09497 - Hall, Alex / Hall, Alex
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03516 - McDonald, Bruce / McDonald, Bruce
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03584 - Bonhoeffer, Sebastian / Bonhoeffer, Sebastian
ethz.grant.agreementno
165803
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Projektförderung in Biologie und Medizin (Abteilung III)
ethz.date.deposited
2017-10-17T12:51:17Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-12-01T10:38:53Z
ethz.rosetta.lastUpdated
2021-02-14T21:01:38Z
ethz.rosetta.versionExported
true
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/215928
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/196595
ethz.COinS
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