High throughput screening for discovery of materials that control stem cell fate
Patel, Asha K.
Tibbitt, Mark W.
Celiz, Adam D.
Davies, Martyn C.
Alexander, Morgan R.
Anderson, Daniel G.
- Journal Article
Rights / licenseCreative Commons Attribution 4.0 International
Insights into the complex stem cell niche have identified the cell–material interface to be a potent regulator of stem cell fate via material properties such as chemistry, topography and stiffness. In light of this, materials scientists have the opportunity to develop bioactive materials for stem cell culture that elicit specific cellular responses. To accelerate materials discovery, high throughput screening platforms have been designed which can rapidly evaluate combinatorial material libraries in two and three-dimensional environments. In this review, we present screening platforms for the discovery of material properties that influence stem cell behavior. Show more
Journal / seriesCurrent Opinion in Solid State & Materials Science
Pages / Article No.
SubjectStem cells; Differentiation; Biomaterials; High throughput screening; 3D
Organisational unit09472 - Tibbitt, Mark / Tibbitt, Mark
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