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dc.contributor.author
Baudouin-Gonzalez, Luís
dc.contributor.author
Santos, Marília A.
dc.contributor.author
Tempesta, Camille
dc.contributor.author
Sucena, Élio
dc.contributor.author
Roch, Fernando
dc.contributor.author
Tanaka, Kohtaro
dc.date.accessioned
2017-12-19T16:50:17Z
dc.date.available
2017-12-12T05:42:39Z
dc.date.available
2017-12-19T16:50:17Z
dc.date.issued
2017-12
dc.identifier.issn
0737-4038
dc.identifier.issn
1537-1719
dc.identifier.other
10.1093/molbev/msx237
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/220107
dc.identifier.doi
10.3929/ethz-b-000220107
dc.description.abstract
Pairs of duplicated genes generally display a combination of conserved expression patterns inherited from their unduplicated ancestor and newly acquired domains. However, how the cis-regulatory architecture of duplicated loci evolves to produce these expression patterns is poorly understood. We have directly examined the gene-regulatory evolution of two tandem duplicates, the Drosophila Ly6 genes CG9336 and CG9338, which arose at the base of the drosophilids between 40 and 60 Ma. Comparing the expression patterns of the two paralogs in four Drosophila species with that of the unduplicated ortholog in the tephritid Ceratitis capitata, we show that they diverged from each other as well as from the unduplicated ortholog. Moreover, the expression divergence appears to have occurred close to the duplication event and also more recently in a lineage-specific manner. The comparison of the tissue-specific cis-regulatory modules (CRMs) controlling the paralog expression in the four Drosophila species indicates that diverse cis-regulatory mechanisms, including the novel tissue-specific enhancers, differential inactivation, and enhancer sharing, contributed to the expression evolution. Our analysis also reveals a surprisingly variable cis-regulatory architecture, in which the CRMs driving conserved expression domains change in number, location, and specificity. Altogether, this study provides a detailed historical account that uncovers a highly dynamic picture of how the paralog expression patterns and their underlying cis-regulatory landscape evolve. We argue that our findings will encourage studying cis-regulatory evolution at the whole-locus level to understand how interactions between enhancers and other regulatory levels shape the evolution of gene expression.
en_US
dc.language.iso
en
en_US
dc.publisher
Oxford University Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc/4.0/
dc.subject
cis-regulatory evolution
en_US
dc.subject
enhancer
en_US
dc.subject
Drosophila
en_US
dc.subject
gene duplication
en_US
dc.subject
gene regulation
en_US
dc.title
Diverse &ITCis&IT-Regulatory Mechanisms Contribute to Expression Evolution of Tandem Gene Duplicates
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial 4.0 International
dc.date.published
2017-09-09
ethz.journal.title
Molecular Biology and Evolution
ethz.journal.volume
34
en_US
ethz.journal.issue
12
en_US
ethz.pages.start
3132
en_US
ethz.pages.end
3147
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-12-12T05:43:11Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-12-19T16:50:20Z
ethz.rosetta.lastUpdated
2018-08-03T03:48:47Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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