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dc.contributor.author
Guadalupe, Tulio
dc.contributor.author
Brem, Silvia
dc.contributor.author
et al.
dc.date.accessioned
2017-12-19T16:26:14Z
dc.date.available
2017-12-12T05:49:20Z
dc.date.available
2017-12-19T16:26:14Z
dc.date.issued
2017-10
dc.identifier.issn
1931-7557
dc.identifier.issn
1931-7565
dc.identifier.other
10.1007/s11682-016-9629-z
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/220137
dc.identifier.doi
10.3929/ethz-b-000220137
dc.description.abstract
The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.
en_US
dc.language.iso
en
en_US
dc.publisher
Springer
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Subcortical brain asymmetry
en_US
dc.subject
Age
en_US
dc.subject
Handedness
en_US
dc.subject
Sex
en_US
dc.subject
Enigma
en_US
dc.subject
Heritability
en_US
dc.subject
Meta-analysis
en_US
dc.title
Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2016-10-13
ethz.journal.title
Brain Imaging and Behavior
ethz.journal.volume
11
en_US
ethz.journal.issue
5
en_US
ethz.journal.abbreviated
Brain imaging behav.
ethz.pages.start
1497
en_US
ethz.pages.end
1514
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
New York, NY
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-12-12T05:49:51Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-12-19T16:26:17Z
ethz.rosetta.lastUpdated
2017-12-19T16:26:17Z
ethz.rosetta.versionExported
true
ethz.COinS
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