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dc.contributor.author
Nicod, Charlotte
dc.contributor.author
Banaei-Esfahani, Amir
dc.contributor.author
Collins, Ben C.
dc.date.accessioned
2018-01-30T16:36:32Z
dc.date.available
2017-12-28T03:29:50Z
dc.date.available
2018-01-30T16:36:32Z
dc.date.issued
2017-10
dc.identifier.issn
1369-5274
dc.identifier.issn
1879-0364
dc.identifier.other
10.1016/j.mib.2017.07.005
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/224621
dc.identifier.doi
10.3929/ethz-b-000224621
dc.description.abstract
Infectious diseases are the result of molecular cross-talks between hosts and their pathogens. These cross-talks are in part mediated by host–pathogen protein–protein interactions (HP-PPI). HP-PPI play crucial roles in infections, as they may tilt the balance either in favor of the pathogens’ spread or their clearance. The identification of host proteins targeted by viral or bacterial pathogenic proteins necessary for the infection can provide insights into their underlying molecular mechanisms of pathogenicity, and potentially even single out pharmacological intervention targets. Here, we review the available methods to study HP-PPI, with a focus on recent mass spectrometry based methods to decipher bacterial–human infectious diseases and examine their relevance in uncovering host cell rewiring by pathogens.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title
Elucidation of host–pathogen protein–protein interactions to uncover mechanisms of host cell rewiring
en_US
dc.type
Review Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2017-08-11
ethz.journal.title
Current Opinion in Microbiology
ethz.journal.volume
39
en_US
ethz.journal.abbreviated
Curr. opin. microbiol.
ethz.pages.start
7
en_US
ethz.pages.end
15
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
The host-pathogen protein interactome of Mycobacterium tuberculosis
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Kidlington
en_US
ethz.publication.status
published
en_US
ethz.grant.agreementno
161435
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Ambizione
ethz.date.deposited
2017-12-28T03:29:54Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-01-30T16:36:36Z
ethz.rosetta.lastUpdated
2018-08-03T04:26:45Z
ethz.rosetta.versionExported
true
ethz.COinS
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