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dc.contributor.author
Baldi, Sandro
dc.contributor.author
Bolognesi, Alessio
dc.contributor.author
Meinema, Anne
dc.contributor.author
Barral, Yves
dc.date.accessioned
2018-01-22T08:36:31Z
dc.date.available
2018-01-10T09:51:17Z
dc.date.available
2018-01-22T08:36:31Z
dc.date.issued
2017-12-28
dc.identifier.issn
2050-084X
dc.identifier.other
10.7554/eLife.28329
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/227026
dc.identifier.doi
10.3929/ethz-b-000227026
dc.description.abstract
Although individuals of many species inexorably age, a number of observations established that the rate of aging is modulated in response to a variety of mild stresses. Here, we investigated how heat stress promotes longevity in yeast. We show that upon growth at higher temperature, yeast cells relax the retention of DNA circles, which act as aging factors in the mother cell. The enhanced frequency at which circles redistribute to daughter cells was not due to changes of anaphase duration or nuclear shape but solely to the downregulation of the diffusion barrier in the nuclear envelope. This effect depended on the PKA and Tor1 pathways, downstream of stress-response kinase Pkc1. Inhibition of these responses restored barrier function and circle retention and abrogated the effect of heat stress on longevity. Our data indicate that redistribution of aging factors from aged cells to their progeny can be a mechanism for modulating longevity.
en_US
dc.format
application/pdf
dc.language.iso
en
en_US
dc.publisher
eLife Sciences Publ.
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Heat stress promotes longevity in budding yeast by relaxing the confinement of age-promoting factors in the mother cell
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
eLife
ethz.journal.volume
6
en_US
ethz.pages.start
e28329
en_US
ethz.size
26 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Cambridge
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02517 - Institut für Biochemie / Institute of Biochemistry (IBC)::03532 - Barral, Yves / Barral, Yves
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02517 - Institut für Biochemie / Institute of Biochemistry (IBC)::03532 - Barral, Yves / Barral, Yves
en_US
ethz.date.deposited
2018-01-10T09:51:18Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-01-22T08:36:36Z
ethz.rosetta.lastUpdated
2022-03-28T18:57:20Z
ethz.rosetta.versionExported
true
ethz.COinS
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