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dc.contributor.author
Dieterich, Lothar C.
dc.contributor.author
Ducoli, Luca
dc.contributor.author
Shin, Jay W.
dc.contributor.author
Detmar, Michael
dc.date.accessioned
2017-12-11T14:22:47Z
dc.date.available
2017-12-11T14:22:47Z
dc.date.available
2017-10-06T02:30:25Z
dc.date.available
2017-11-16T11:12:13Z
dc.date.issued
2017-08-29
dc.identifier.issn
2052-4463
dc.identifier.other
10.1038/sdata.2017.106
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/227573
dc.identifier.doi
10.3929/ethz-b-000190817
dc.description.abstract
Vascular endothelial growth factors (VEGFs) and their receptors play crucial roles in the formation of blood and lymphatic vessels during embryogenesis, and also under pathologic conditions in the adult. Despite intensive efforts over the last decades to elucidate the precise functions of VEGFs, transcriptional responses to VEGF receptor stimulation are still not fully characterized. To investigate the specific transcriptional effects of VEGFR-2 and VEGFR-3 activation, we performed a correlation analysis of previously published CAGE sequencing and microarray data of human lymphatic endothelial cells (LECs) stimulated with distinct VEGFs acting through either VEGFR-2 or VEGFR-3. We identified that specific activation of VEGFR-3 by VEGF-C156S results in the downregulation of many genes involved in immune regulation and inflammation, suggesting that VEGFR-3 stimulation has direct anti-inflammatory effects. Comparing CAGE and microarray data sets, we furthermore identified a small number of genes that showed a receptor-dependent response in LECs, demonstrating that these receptors, despite activating very similar signaling pathways, fulfill overlapping but not identical functions within the same cell type (LECs).
en_US
dc.format
application/pdf
dc.language.iso
en
en_US
dc.publisher
Nature
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Growth factor signalling
en_US
dc.subject
Transcriptomics
en_US
dc.title
Distinct transcriptional responses of lymphatic endothelial cells to VEGFR-3 and VEGFR-2 stimulation
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
Scientific Data
ethz.journal.volume
4
en_US
ethz.pages.start
170106
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03683 - Detmar, Michael / Detmar, Michael
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03683 - Detmar, Michael / Detmar, Michael
en_US
ethz.date.deposited
2017-10-06T02:30:35Z
ethz.source
FORM
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-01-11T11:19:08Z
ethz.rosetta.lastUpdated
2021-02-14T21:44:49Z
ethz.rosetta.versionExported
true
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/219822
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/190817
ethz.COinS
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