Combination of a microfluidic device and fluorescence correlation spectroscopy to study peptide translocation across model membranes
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This paper reports a microfluidic device that allows for trapping, treatment, and analysis of up to 192 individual giant unilamellar vesicles (GUVs) to study the translocation of fluorescently labeled cell-penetrating peptides (CPPs) across model membranes by fluorescence correlation spectroscopy (FCS). The results indicate that the composition of the membrane influences the membrane permeability of the tested CPPs. Show more
Book title21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017)
Pages / Article No.
PublisherChemical and Biological Microsystems Society
SubjectFluorescence correlation spectroscopy (FCS); Giant unilamellar vesicles (GUVs); Permeation; Membrane translocation; Cell-penetrating peptides (CPPs)
Organisational unit02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.
03807 - Dittrich, Petra / Dittrich, Petra
681587 - Engineering of hybrid cells using lab-on-chip technology (EC)
NotesExtended abstract. Poster presentation on October 23, 2017.
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