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dc.contributor.author
Armbrecht, Lucas
dc.contributor.author
Gabernet, Gisela
dc.contributor.author
Kurth, Felix
dc.contributor.author
Hiss, Jan Alexander
dc.contributor.author
Schneider, Gisbert
dc.contributor.author
Dittrich, Petra S.
dc.date.accessioned
2020-02-20T07:07:07Z
dc.date.available
2018-01-15T14:43:15Z
dc.date.available
2018-03-22T14:04:27Z
dc.date.available
2018-03-22T16:05:27Z
dc.date.available
2020-02-17T08:30:34Z
dc.date.available
2020-02-20T07:07:07Z
dc.date.issued
2017
dc.identifier.isbn
978-0-692-94183-6
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/228839
dc.description.abstract
We report a microfluidic chip that can capture and isolate up to 612 single mammalian cells to monitor the ef-fect of treatment with anticancer peptides Aurein 1.2 and Aurein 2.2. Therefore, single breast adenocarcinoma cells (MCF-7) were confined in microfluidic chambers with a volume of less than 100 pl. Doughnut-shaped valves enabled us to quickly exchange solutions on demand to expose single cells to the membranolytic anti-cancer peptide (ACP) of interest. Automated fluorescence microscopy is employed to monitor the heterogeneous cellular response in all 612 chambers at high temporal resolution.
en_US
dc.language.iso
en
en_US
dc.publisher
Chemical and Biological Microsystems Society
en_US
dc.subject
Single-cell analysis
en_US
dc.subject
Drug response monitoring
en_US
dc.subject
Anticancer peptides
en_US
dc.subject
Microfluidics
en_US
dc.title
Monitoring the response of single MCF-7 cells to anticancer peptides on a microfluidic chip
en_US
dc.type
Other Conference Item
ethz.book.title
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017)
en_US
ethz.pages.start
239
en_US
ethz.pages.end
240
en_US
ethz.event
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2017)
en_US
ethz.event.location
Savannah, GA, USA
en_US
ethz.event.date
October 22-26, 2017
en_US
ethz.notes
Conference lecture held on October 26, 2017.
en_US
ethz.grant
Engineering of hybrid cells using lab-on-chip technology
en_US
ethz.grant
Experiment-guided computational de novo exploration of peptide-membrane interaction
en_US
ethz.grant
Engineering the Targeted Drugs of the Future: A General Approach
en_US
ethz.publication.place
San Diego, CA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03807 - Dittrich, Petra / Dittrich, Petra
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03807 - Dittrich, Petra / Dittrich, Petra
ethz.grant.agreementno
681587
ethz.grant.agreementno
157190
ethz.grant.agreementno
160699
ethz.grant.agreementno
681587
ethz.grant.agreementno
157190
ethz.grant.agreementno
160699
ethz.grant.agreementno
681587
ethz.grant.agreementno
157190
ethz.grant.agreementno
160699
ethz.grant.agreementno
681587
ethz.grant.agreementno
157190
ethz.grant.agreementno
160699
ethz.grant.fundername
EC
ethz.grant.fundername
SNF
ethz.grant.fundername
SNF
ethz.grant.fundername
EC
ethz.grant.fundername
SNF
ethz.grant.fundername
SNF
ethz.grant.fundername
EC
ethz.grant.fundername
SNF
ethz.grant.fundername
SNF
ethz.grant.fundername
EC
ethz.grant.fundername
SNF
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100000780
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100000780
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100000780
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100000780
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
H2020
ethz.grant.program
Projektförderung in Mathematik, Natur- und Ingenieurwissenschaften (Abteilung II)
ethz.grant.program
H2020
ethz.grant.program
Projektförderung in Mathematik, Natur- und Ingenieurwissenschaften (Abteilung II)
ethz.grant.program
H2020
ethz.grant.program
Projektförderung in Mathematik, Natur- und Ingenieurwissenschaften (Abteilung II)
ethz.grant.program
Sinergia
ethz.grant.program
H2020
ethz.grant.program
Projektförderung in Mathematik, Natur- und Ingenieurwissenschaften (Abteilung II)
ethz.grant.program
Sinergia
ethz.date.deposited
2018-01-15T14:43:15Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2018-03-22T14:04:30Z
ethz.rosetta.lastUpdated
2022-03-29T01:02:02Z
ethz.rosetta.versionExported
true
ethz.COinS
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