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dc.contributor.author
Liu, Yilei
dc.contributor.author
Lardi, Martina
dc.contributor.author
Pedrioli, Alessandro
dc.contributor.author
Eberl, Leo
dc.contributor.author
Pessi, Gabriella
dc.date.accessioned
2018-02-14T14:35:16Z
dc.date.available
2018-01-18T14:07:55Z
dc.date.available
2018-02-14T14:35:16Z
dc.date.issued
2017
dc.identifier.issn
1932-6203
dc.identifier.other
10.1371/journal.pone.0180362
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/230915
dc.identifier.doi
10.3929/ethz-b-000230915
dc.description.abstract
Burkholderia cenocepacia is a versatile opportunistic pathogen that survives in a wide variety of environments, which can be limited in nutrients such as nitrogen. We have previously shown that the sigma factor sigma54 is involved in the control of nitrogen assimilation and virulence in B. cenocepacia H111. In this work, we investigated the role of the sigma54 enhancer binding protein NtrC in response to nitrogen limitation and in the pathogenicity of H111. Of 95 alternative nitrogen sources tested the ntrC showed defects in the utilisation of nitrate, urea, L-citrulline, acetamide, DL-lactamide, allantoin and parabanic acid. RNA-Seq and phenotypic analyses of an ntrC mutant strain showed that NtrC positively regulates two important phenotypic traits: exopolysaccharide (EPS) production and motility. However, the ntrC mutant was not attenuated in C. elegans virulence.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Animals
en_US
dc.title
NtrC-dependent control of exopolysaccharide synthesis and motility in Burkholderia cenocepacia H111
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2017-06-29
ethz.journal.title
PLoS ONE
ethz.journal.volume
12
en_US
ethz.journal.issue
6
en_US
ethz.journal.abbreviated
PLoS ONE
ethz.pages.start
e0180362
en_US
ethz.size
22 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.publication.place
San Francisco, CA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00003 - Schulleitung und Dienste::00022 - Bereich VP Forschung & Wirtschaftsbez. / Domain VP Research & Corporate Relations::02207 - Functional Genomics Center Zürich / Functional Genomics Center Zürich
en_US
ethz.date.deposited
2018-01-18T14:07:56Z
ethz.source
BATCH
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-02-14T14:35:23Z
ethz.rosetta.lastUpdated
2018-11-06T09:41:22Z
ethz.rosetta.versionExported
true
ethz.COinS
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