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dc.contributor.author
Krackow, Sven
dc.contributor.author
Vannoni, Elisabetta
dc.contributor.author
Codita, Alina
dc.contributor.author
Mohammed, Abdul H.
dc.contributor.author
Cirulli, Francesca
dc.contributor.author
Branchi, Igor
dc.contributor.author
Alleva, Enrico
dc.contributor.author
Reichelt, Anja
dc.contributor.author
Willuweit, Antje
dc.contributor.author
Voikar, Vootele
dc.contributor.author
Colacicco, Giovanni
dc.contributor.author
Wolfer, David Paul
dc.contributor.author
Buschmann, Jens-Uwe F.
dc.contributor.author
Safi, Kamran
dc.contributor.author
Lipp, Hans-Peter
dc.date.accessioned
2021-03-01T10:12:30Z
dc.date.available
2017-06-09T05:42:58Z
dc.date.available
2021-03-01T10:12:30Z
dc.date.issued
2010-10
dc.identifier.issn
1601-1848
dc.identifier.issn
1601-183X
dc.identifier.other
10.1111/j.1601-183X.2010.00606.x
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/23299
dc.description.abstract
The between‐laboratory effects on behavioral phenotypes and spatial learning performance of three strains of laboratory mice known for divergent behavioral phenotypes were evaluated in a fully balanced and synchronized study using a completely automated behavioral phenotyping device (IntelliCage). Activity pattern and spatial conditioning performance differed consistently between strains, i.e. exhibited no interaction with the between‐laboratory factor, whereas the gross laboratory effect showed up significantly in the majority of measures. It is argued that overall differences between laboratories may not realistically be preventable, as subtle differences in animal housing and treatment will not be controllable, in practice. However, consistency of strain (or treatment) effects appears to be far more important in behavioral and brain sciences than the absolute overall level of such measures. In this respect, basic behavioral and learning measures proved to be highly consistent in the IntelliCage, therefore providing a valid basis for meaningful research hypothesis testing. Also, potential heterogeneity of behavioral status because of environmental and social enrichment has no detectable negative effect on the consistency of strain effects. We suggest that the absence of human interference during behavioral testing is the most prominent advantage of the IntelliCage and suspect that this is likely responsible for the between‐laboratory consistency of findings, although we are aware that this ultimately needs direct testing.
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley-Blackwell
en_US
dc.subject
Automated behavioral screening
en_US
dc.subject
Between-laboratory standardization
en_US
dc.subject
Environmental enrichment
en_US
dc.subject
Home cage behavioral testing
en_US
dc.subject
High-throughput phenotyping
en_US
dc.subject
Reversal learning
en_US
dc.subject
Spatial preference conditioning
en_US
dc.title
Consistent behavioral phenotype differences between inbred mouse strains in the IntelliCage
en_US
dc.type
Journal Article
dc.date.published
2010-06-02
ethz.journal.title
Genes, Brain and Behavior
ethz.journal.volume
9
en_US
ethz.journal.issue
7
en_US
ethz.journal.abbreviated
Genes Brain Behav
ethz.pages.start
722
en_US
ethz.pages.end
731
en_US
ethz.identifier.wos
ethz.identifier.nebis
004510131
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::03727 - Wolfer, David P. / Wolfer, David P.
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::03727 - Wolfer, David P. / Wolfer, David P.
ethz.date.deposited
2017-06-09T05:43:08Z
ethz.source
ECIT
ethz.identifier.importid
imp59364d10736da60097
ethz.ecitpid
pub:38332
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2017-07-26T18:55:36Z
ethz.rosetta.lastUpdated
2022-03-29T05:30:18Z
ethz.rosetta.versionExported
true
ethz.COinS
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