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dc.contributor.author
Koestinger, German
dc.contributor.author
Martin, Kevan A.C.
dc.contributor.author
Rusch, Elisha S.
dc.date.accessioned
2020-06-18T05:27:47Z
dc.date.available
2018-01-24T14:43:48Z
dc.date.available
2018-01-29T13:55:50Z
dc.date.available
2020-06-18T05:27:47Z
dc.date.issued
2018-05
dc.identifier.other
10.1007/s00429-017-1588-7
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/233796
dc.identifier.doi
10.3929/ethz-b-000233796
dc.description.abstract
Pyramidal cells in the superficial layers of the neocortex provide a major excitatory projection to layer 5, which contains the pyramidal cells that project to subcortical motor-related targets. Both structurally and functionally rather little is known about this interlaminar pathway, especially in higher mammals. Here, we made sparse ultrastructural reconstructions of the projection to layer 5 of three pyramidal neurons from layer 3 in cat V1 whose morphology, physiology, and synaptic connections with layers 2 and 3 were known. The dominant targets of the 74 identified synapses in layer 5 were the dendritic spines of pyramidal cells. The fractions of target spiny dendrites were 59, 61, and 84% for the three cells, with the remaining targets being dendrites of smooth neurons. These fractions were similar to the distribution of targets of unlabeled asymmetric synapses in the surrounding neuropil. Serial section reconstructions revealed that the target dendrites were heterogenous in morphology, indicating that different cell types are innervated. This new evidence indicates that the descending projection from the superficial layer pyramidal cells does not simply drive the output pyramidal cells that project to cortical and subcortical targets, but participates in the complex circuitry of the deep cortical layers.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Springer
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Visual cortex
en_US
dc.subject
Pyramidal neuron
en_US
dc.subject
Layer 5
en_US
dc.subject
Dendrite
en_US
dc.subject
Synapse
en_US
dc.subject
Postsynaptic target
en_US
dc.title
Translaminar circuits formed by the pyramidal cells in the superficial layers of cat visual cortex
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2017-12-12
ethz.journal.title
Brain Structure and Function
ethz.journal.volume
223
en_US
ethz.journal.issue
4
en_US
ethz.pages.start
1811
en_US
ethz.pages.end
1828
en_US
ethz.size
18 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Berlin
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Departement Informationstechnologie und Elektrotechnik / Department of Information Technology and Electrical Engineering::02533 - Institut für Neuroinformatik (INI) / Institute of Neuroinformatics (INI)::03454 - Martin, Kevan A.C. (emeritus)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Departement Informationstechnologie und Elektrotechnik / Department of Information Technology and Electrical Engineering::02533 - Institut für Neuroinformatik (INI) / Institute of Neuroinformatics (INI)::03454 - Martin, Kevan A.C. (emeritus)
en_US
ethz.date.deposited
2018-01-24T14:43:48Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-01-29T13:55:56Z
ethz.rosetta.lastUpdated
2021-02-15T14:44:38Z
ethz.rosetta.versionExported
true
ethz.COinS
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