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dc.contributor.author
Mitroulis, Ioannis
dc.contributor.author
Ruppova, Klara
dc.contributor.author
Wang, Baomei
dc.contributor.author
Chen, Lan-Sun
dc.contributor.author
Grzybek, Michal
dc.contributor.author
Grinenko, Tatyana
dc.contributor.author
Eugster, Anne
dc.contributor.author
Troullinaki, Maria
dc.contributor.author
Palladini, Alessandra
dc.contributor.author
Kourtzelis, Ioannis
dc.contributor.author
Chatzigeorgiou, Antonios
dc.contributor.author
Schlitzer, Andreas
dc.contributor.author
Beyer, Marc
dc.contributor.author
Joosten, Leo A.B.
dc.contributor.author
Isermann, Berend
dc.contributor.author
Lesche, Mathias
dc.contributor.author
Petzold, Andreas
dc.contributor.author
Simons, Kai
dc.contributor.author
Henry, Ian
dc.contributor.author
Dahl, Andreas
dc.contributor.author
Schultze, Joachim L.
dc.contributor.author
Wielockx, Ben
dc.contributor.author
Zamboni, Nicola
dc.contributor.author
Mirtschink, Peter
dc.contributor.author
Coskun, Ünal
dc.contributor.author
Hajishengallis, George
dc.contributor.author
Netea, Mihai G.
dc.contributor.author
Chavakis, Triantafyllos
dc.date.accessioned
2018-03-23T11:13:59Z
dc.date.available
2018-01-26T03:07:40Z
dc.date.available
2018-03-23T11:13:59Z
dc.date.issued
2018-01-11
dc.identifier.other
10.1016/j.cell.2017.11.034
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/234959
dc.identifier.doi
10.3929/ethz-b-000234959
dc.description.abstract
Trained innate immunity fosters a sustained favorable response of myeloid cells to a secondary challenge, despite their short lifespan in circulation. We thus hypothesized that trained immunity acts via modulation of hematopoietic stem and progenitor cells (HSPCs). Administration of β-glucan (prototypical trained-immunity-inducing agonist) to mice induced expansion of progenitors of the myeloid lineage, which was associated with elevated signaling by innate immune mediators, such as IL-1β and granulocyte-macrophage colony-stimulating factor (GM-CSF), and with adaptations in glucose metabolism and cholesterol biosynthesis. The trained-immunity-related increase in myelopoiesis resulted in a beneficial response to secondary LPS challenge and protection from chemotherapy-induced myelosuppression in mice. Therefore, modulation of myeloid progenitors in the bone marrow is an integral component of trained immunity, which to date, was considered to involve functional changes of mature myeloid cells in the periphery.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Cell Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title
Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
ethz.journal.title
CELL
ethz.journal.volume
172
en_US
ethz.journal.issue
1-2
en_US
ethz.pages.start
147
en_US
ethz.pages.end
161.e12
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Cambridge, MA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03713 - Sauer, Uwe / Sauer, Uwe
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03713 - Sauer, Uwe / Sauer, Uwe
ethz.date.deposited
2018-01-26T03:08:20Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-03-23T11:14:08Z
ethz.rosetta.lastUpdated
2019-02-02T16:22:02Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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