Specific Targeting of Melanotic Cells with Peptide Ligated Photosensitizers for Photodynamic Therapy
Bigliardi, Paul L.
Eberle, Alex N.
Burkett, Brendan A.
- Journal Article
Rights / licenseCreative Commons Attribution 4.0 International
A strategy combining covalent conjugation of photosensitizers to a peptide ligand directed to the melanocortin 1 (MC1) receptor with the application of sequential LED light dosage at near-IR wavelengths was developed to achieve specific cytotoxicity to melanocytes and melanoma (MEL) with minimal collateral damage to surrounding cells such as keratinocytes (KER). The specific killing of melanotic cells by targeted photodynamic therapy (PDT) described in this study holds promise as a potentially effective adjuvant therapeutic method to control benign skin hyperpigmentation or superficial melanotic malignancy such as Lentigo Maligna Melanoma (LMM) Show more
Journal / seriesScientific Reports
PublisherNature Publishing Group
SubjectImaging studies; Melanoma; Peptides
Organisational unit02803 - Collegium Helveticum / Collegium Helveticum
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