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dc.contributor.author
Wang, Congwei
dc.contributor.author
Schmich, Fabian
dc.contributor.author
Weidner, Julie
dc.contributor.author
Beerenwinkel, Niko
dc.contributor.author
Spang, Anne
dc.date.accessioned
2018-04-10T14:08:18Z
dc.date.available
2018-01-26T14:55:44Z
dc.date.available
2018-01-30T14:48:43Z
dc.date.available
2018-04-10T12:44:17Z
dc.date.available
2018-04-10T14:08:18Z
dc.date.issued
2018
dc.identifier.other
10.1101/159376
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/235380
dc.identifier.doi
10.3929/ethz-b-000235380
dc.description.abstract
Cells respond to stress by remodeling their transcriptome through transcription and degradation. Xrn1p-dependent degradation in P-bodies is the most prevalent pathway. Yet, P-bodies may facilitate not only decay but also act as storage compartment. However, which and how mRNAs are selected into different degradation pathways and what determines the fate of any given mRNA in P-bodies remain largely unknown. We devised a new method to identify both common and stress-specific mRNA subsets associated with P-bodies. mRNAs targeted for degradation to P-bodies, decayed with different kinetics. Moreover, the localization of a specific set of mRNAs in P-bodies under glucose deprivation was obligatory to prevent decay. Depending on its client mRNA, the RNA binding protein Puf5p either promoted or inhibited decay. The Puf5p-dependent storage of a subset of mRNAs in P-bodies under glucose starvation may be beneficial with respect to chronological lifespan.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Cold Spring Harbor Laboratory
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Context-dependent deposition and regulation of mRNAs in P-bodies
en_US
dc.type
Working Paper
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2017-07-04
ethz.journal.title
bioRxiv
ethz.pages.start
159376
en_US
ethz.size
45 p.
en_US
ethz.publication.place
Cold Spring Harbor, NY
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03790 - Beerenwinkel, Niko / Beerenwinkel, Niko
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03790 - Beerenwinkel, Niko / Beerenwinkel, Niko
en_US
ethz.relation.isPreviousVersionOf
10.3929/ethz-b-000244454
ethz.date.deposited
2018-01-26T14:55:45Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-04-10T14:08:39Z
ethz.rosetta.lastUpdated
2022-03-28T19:41:47Z
ethz.rosetta.versionExported
true
ethz.COinS
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