A microfluidic hanging-drop system to study the secretion dynamics of single pancreatic iIslet microtissues
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We present an analytical microfluidic system that employs uniform re-aggregated islets to study glucosestimulated insulin secretion (GSIS). The high sampling rate enables to resolve the physiologically characteristic biphasic and pulsatile insulin release from healthy β-cells of the pancreatic islets. Loss of the first phase, reduction in the second phase and impairment of the oscillatory pattern of insulin secretion are characteristic features of type 2 diabetes. Therefore, investigation of the dynamics of insulin secretion is important to understand the pathophysiology of diabetes as well as to study pharmacokinetics and the mechanisms of anti-diabetic medication. Show more
Book title21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017)
Pages / Article No.
PublisherChemical and Biological Microsystems Society
SubjectMicrofluidics; Hanging drop; 3D microtissue; GSIS; Pancreatic islets
Organisational unit03684 - Hierlemann, Andreas / Hierlemann, Andreas
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NotesPoster abstract. Poster presentation on October 26, 2017.
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