A microfluidic hanging-drop system to study the secretion dynamics of single pancreatic iIslet microtissues
- Other Conference Item
We present an analytical microfluidic system that employs uniform re-aggregated islets to study glucosestimulated insulin secretion (GSIS). The high sampling rate enables to resolve the physiologically characteristic biphasic and pulsatile insulin release from healthy β-cells of the pancreatic islets. Loss of the first phase, reduction in the second phase and impairment of the oscillatory pattern of insulin secretion are characteristic features of type 2 diabetes. Therefore, investigation of the dynamics of insulin secretion is important to understand the pathophysiology of diabetes as well as to study pharmacokinetics and the mechanisms of anti-diabetic medication. Show more
External linksSearch via SFX
Book title21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2017)
Pages / Article No.
PublisherChemical and Biological Microsystems Society
SubjectMicrofluidics; Hanging drop; 3D microtissue; GSIS; Pancreatic islets
Organisational unit03684 - Hierlemann, Andreas / Hierlemann, Andreas
166329 - “Infected Body-on-a-Chip”: Microfluidic Impedance Platform for Antischistosomal Drug Discovery (SNF)
Related publications and datasets
NotesPoster abstract. Poster presentation on October 26, 2017.
MoreShow all metadata