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dc.contributor.author
Rousset, Nassim
dc.contributor.author
De Geus, Martina
dc.contributor.author
Kaestli, Alicia J.
dc.contributor.author
Renggli, Kasper
dc.contributor.author
Hierlemann, Andreas
dc.date.accessioned
2020-02-20T09:18:13Z
dc.date.available
2018-01-30T16:28:03Z
dc.date.available
2018-01-31T06:51:42Z
dc.date.available
2020-02-20T09:18:13Z
dc.date.issued
2017
dc.identifier.isbn
978-0-692-94183-6
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/237349
dc.description.abstract
Few “body-on-a-chip” systems incorporate the circulation of cells between tissues despite its vital role in connecting organs in vivo. To include this component, we added flowing single cells to a hanging-drop network, a modular microfluidic platform used to study multi-tissue interactions. To obviate stagnation of circulating cells at the bottom of hanging drops, we used finite-element modeling and broad parameter sweeps on drop dimensions to map forces acting on cells at the air-liquid interface. This model suggested an optimal range of drop height to aperture radius ratios, which would ensure long-term cell circulation through a hanging-drop network.
en_US
dc.language.iso
en
en_US
dc.publisher
Chemical and Biological Microsystems Society
en_US
dc.subject
Hanging-drop networks
en_US
dc.subject
Flowing cells
en_US
dc.subject
Microphysiological systems
en_US
dc.subject
Air-liquid interface
en_US
dc.title
Modeling of hanging-drop networks to optimize the mobility of flowing cells in a physiological environment
en_US
dc.type
Other Conference Item
ethz.book.title
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017)
en_US
ethz.pages.start
1173
en_US
ethz.pages.end
1174
en_US
ethz.event
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2017)
en_US
ethz.event.location
Savannah, GA, USA
en_US
ethz.event.date
October 22-26, 2017
en_US
ethz.notes
Poster abstract. Poster presentation on October 25, 2017.
en_US
ethz.publication.place
San Diego, CA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03684 - Hierlemann, Andreas / Hierlemann, Andreas
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03684 - Hierlemann, Andreas / Hierlemann, Andreas
en_US
ethz.date.deposited
2018-01-30T16:28:03Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2018-01-31T06:51:46Z
ethz.rosetta.lastUpdated
2022-03-29T01:02:14Z
ethz.rosetta.versionExported
true
ethz.COinS
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