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dc.contributor.author
Lovric, Goran
dc.contributor.author
Mokso, Rajmund
dc.contributor.author
Arcadu, Filippo
dc.contributor.author
Vogiatzis Oikonomidis, Ioannis
dc.contributor.author
Schittny, Johannes C.
dc.contributor.author
Roth-Kleiner, Matthias
dc.contributor.author
Stampanoni, Marco
dc.date.accessioned
2018-01-15T12:44:38Z
dc.date.available
2018-01-15T12:44:38Z
dc.date.available
2017-10-19T02:18:10Z
dc.date.available
2017-11-01T13:39:37Z
dc.date.issued
2017-12
dc.identifier.issn
2045-2322
dc.identifier.other
10.1038/s41598-017-12886-3
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/238777
dc.identifier.doi
10.3929/ethz-b-000197792
dc.description.abstract
Lungs represent the essential part of the mammalian respiratory system, which is reflected in the fact that lung failure still is one of the leading causes of morbidity and mortality worldwide. Establishing the connection between macroscopic observations of inspiration and expiration and the processes taking place at the microscopic scale remains crucial to understand fundamental physiological and pathological processes. Here we demonstrate for the first time in vivo synchrotron-based tomographic imaging of lungs with pixel sizes down to a micrometer, enabling first insights into high-resolution lung structure. We report the methodological ability to study lung inflation patterns at the alveolar scale and its potential in resolving still open questions in lung physiology. As a first application, we identified heterogeneous distension patterns at the alveolar level and assessed first comparisons of lungs between the in vivo and immediate post mortem states.
en_US
dc.format
application/pdf
dc.language.iso
en
en_US
dc.publisher
Nature
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Tomographic in vivo microscopy for the study of lung physiology at the alveolar level
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2017-10-02
ethz.journal.title
Scientific Reports
ethz.journal.volume
7
en_US
ethz.journal.abbreviated
Sci Rep
ethz.pages.start
12545
en_US
ethz.size
10 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
In-vivo study of lung physiology with sub-second X-ray tomographic microscopy
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::03817 - Stampanoni, Marco F.M. / Stampanoni, Marco F.M.
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::03817 - Stampanoni, Marco F.M. / Stampanoni, Marco F.M.
en_US
ethz.grant.agreementno
135550
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Interdisziplinäres Projekt
ethz.date.deposited
2017-10-19T02:18:13Z
ethz.source
FORM
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-02-05T14:15:45Z
ethz.rosetta.lastUpdated
2024-02-02T03:53:16Z
ethz.rosetta.versionExported
true
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/228684
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/197792
ethz.COinS
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