Zur Kurzanzeige

dc.contributor.author
Greiff, Victor
dc.contributor.author
Menzel, Ulrike
dc.contributor.author
Miho, Enkelejda
dc.contributor.author
Weber, Cédric
dc.contributor.author
Riedel, René
dc.contributor.author
Cook, Skylar
dc.contributor.author
Valai, Atijeh
dc.contributor.author
Lopes, Telma
dc.contributor.author
Radbruch, Andreas
dc.contributor.author
Winkler, Thomas H.
dc.contributor.author
Reddy, Sai T.
dc.date.accessioned
2018-02-12T08:57:33Z
dc.date.available
2017-10-06T02:44:58Z
dc.date.available
2017-10-12T09:00:49Z
dc.date.available
2018-02-12T08:57:33Z
dc.date.issued
2017-05-16
dc.identifier.issn
2666-3864
dc.identifier.issn
2211-1247
dc.identifier.other
10.1016/j.celrep.2017.04.054
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/239957
dc.identifier.doi
10.3929/ethz-b-000191023
dc.description.abstract
Antibody repertoire diversity and plasticity is crucial for broad protective immunity. Repertoires change in size and diversity across multiple B cell develop- mental stages and in response to antigen exposure. However,westilllackfundamentalquantitativeunder- standing of the extent to which repertoire diversity is predetermined. Therefore, we implemented a sys- tems immunology framework for quantifying reper- toire predetermination on three distinct levels: (1) B cell development (pre-B cell, naive B cell, plasma cell), (2) antigen exposure (three structurally different proteins),and(3)fourantibodyrepertoirecomponents (V-gene usage, clonal expansion, clonal diversity, repertoire size) extracted from antibody repertoire sequencing data (400 million reads). Across all three levels, we detected a dynamic balance of high genetic (e.g., >90% for V-gene usage and clonal expansion in naive B cells) and antigen-driven (e.g., 40% for clonal diversity in plasma cells) predetermination and sto- chastic variation. Our study has implications for the prediction and manipulation of humoral immunity.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title
Systems Analysis Reveals High Genetic and Antigen-Driven Predetermination of Antibody Repertoires throughout B Cell Development
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2017-05-16
ethz.journal.title
Cell Reports
ethz.journal.volume
19
en_US
ethz.journal.issue
7
en_US
ethz.journal.abbreviated
Cell Rep
ethz.pages.start
1467
en_US
ethz.pages.end
1478
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03952 - Reddy, Sai / Reddy, Sai
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03952 - Reddy, Sai / Reddy, Sai
en_US
ethz.date.deposited
2017-10-06T02:45:14Z
ethz.source
FORM
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-02-12T08:53:48Z
ethz.rosetta.lastUpdated
2022-03-28T19:09:08Z
ethz.rosetta.versionExported
true
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/235234
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/191023
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Systems%20Analysis%20Reveals%20High%20Genetic%20and%20Antigen-Driven%20Predetermination%20of%20Antibody%20Repertoires%20throughout%20B%20Cell%20Development&rft.jtitle=Cell%20Reports&rft.date=2017-05-16&rft.volume=19&rft.issue=7&rft.spage=1467&rft.epage=1478&rft.issn=2666-3864&2211-1247&rft.au=Greiff,%20Victor&Menzel,%20Ulrike&Miho,%20Enkelejda&Weber,%20C%C3%A9dric&Riedel,%20Ren%C3%A9&rft.genre=article&rft_id=info:doi/10.1016/j.celrep.2017.04.054&
 Printexemplar via ETH-Bibliothek suchen

Dateien zu diesem Eintrag

Thumbnail

Publikationstyp

Zur Kurzanzeige