- Journal Article
Rights / licenseCreative Commons Attribution 4.0 International
Background The ability to form a cellular memory and use it for cellular decision-making could help bacteria to cope with recurrent stress conditions. We analyzed whether bacteria would form a cellular memory specifically if past events are predictive of future conditions. We worked with the asymmetrically dividing bacterium Caulobacter crescentus where past events are expected to only be informative for one of the two cells emerging from division, the sessile cell that remains in the same microenvironment and does not migrate. Results Time-resolved analysis of individual cells revealed that past exposure to low levels of antibiotics increases tolerance to future exposure for the sessile but not for the motile cell. Using computer simulations, we found that such an asymmetry in cellular memory could be an evolutionary response to situations where the two cells emerging from division will experience different future conditions. Conclusions Our results raise the question whether bacteria can evolve the ability to form and use cellular memory conditionally in situations where it is beneficial Show more
Journal / seriesBMC Evolutionary Biology
Pages / Article No.
SubjectBacterial memory; Priming; Caulobacter crescentus; Asymmetry
Organisational unit03743 - Ackermann, Martin / Ackermann, Martin
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