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dc.contributor.author
da Silva, Ronan V.
dc.contributor.author
Johannssen, Helge C.
dc.contributor.author
Wyss, Matthias T.
dc.contributor.author
Roome, R. Brian
dc.contributor.author
Bourojeni, Farin B.
dc.contributor.author
Stifani, Nicolas
dc.contributor.author
Marsh, Ashley P.L.
dc.contributor.author
Ryan, Monique M.
dc.contributor.author
Lockhart, Paul J.
dc.contributor.author
Leventer, Richard J.
dc.contributor.author
Richards, Linda J.
dc.contributor.author
Rosenblatt, Bernard
dc.contributor.author
Srour, Myriam
dc.contributor.author
Weber, Bruno
dc.contributor.author
Zeilhofer, Hanns U.
dc.contributor.author
Kania, Artur
dc.date.accessioned
2019-07-17T14:31:10Z
dc.date.available
2018-02-15T03:16:57Z
dc.date.available
2018-03-23T11:54:44Z
dc.date.available
2019-07-17T14:31:10Z
dc.date.issued
2018-01-30
dc.identifier.other
10.1016/j.celrep.2018.01.004
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/240894
dc.identifier.doi
10.3929/ethz-b-000240894
dc.description.abstract
Avoidance of environmental dangers depends on nociceptive topognosis, or the ability to localize painful stimuli. This is proposed to rely on somatotopic maps arising from topographically organized point-to-point connections between the body surface and the CNS. To determine the role of topographic organization of spinal ascending projections in nociceptive topognosis, we generated a conditional knockout mouse lacking expression of the netrin1 receptor DCC in the spinal cord. These mice have an increased number of ipsilateral spinothalamic connections and exhibit aberrant activation of the somatosensory cortex in response to unilateral stimulation. Furthermore, spinal cord-specific Dcc knockout animals displayed mislocalized licking responses to formalin injection, indicating impaired topognosis. Similarly, humans with DCC mutations experience bilateral sensation evoked by unilateral somatosensory stimulation. Collectively, our results constitute functional evidence of the importance of topographic organization of spinofugal connections for nociceptive topognosis.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
topographic organization
en_US
dc.subject
nociception
en_US
dc.subject
spinothalamic
en_US
dc.subject
DCC
en_US
dc.subject
commissural
en_US
dc.subject
behavior
en_US
dc.subject
mutation
en_US
dc.subject
mirror movement disorder
en_US
dc.subject
pain
en_US
dc.subject
somatosensory system
en_US
dc.subject
human genetics
en_US
dc.title
DCC Is Required for the Development of Nociceptive Topognosis in Mice and Humans
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2018-01-31
ethz.journal.title
Cell Reports
ethz.journal.volume
22
en_US
ethz.journal.issue
5
en_US
ethz.pages.start
1105
en_US
ethz.pages.end
1114
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
New York, NY
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03742 - Zeilhofer, Hanns U. / Zeilhofer, Hanns U.
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03742 - Zeilhofer, Hanns U. / Zeilhofer, Hanns U.
ethz.date.deposited
2018-02-15T03:17:14Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-03-23T11:54:48Z
ethz.rosetta.lastUpdated
2019-07-17T14:31:21Z
ethz.rosetta.versionExported
true
ethz.COinS
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