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dc.contributor.author
Parfejevs, Vadims
dc.contributor.author
Debbache, Julien
dc.contributor.author
Shakhova, Olga
dc.contributor.author
Schaefer, Simon M.
dc.contributor.author
Glausch, Mareen
dc.contributor.author
Wegner, Michael
dc.contributor.author
Suter, Ueli
dc.contributor.author
Riekstina, Una
dc.contributor.author
Werner, Sabine
dc.contributor.author
Sommer, Lukas
dc.date.accessioned
2018-02-19T13:49:41Z
dc.date.available
2018-01-03T14:41:00Z
dc.date.available
2018-02-19T13:47:56Z
dc.date.available
2018-01-28T02:47:23Z
dc.date.available
2018-02-19T13:49:41Z
dc.date.issued
2018
dc.identifier.other
10.1038/s41467-017-01488-2
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/242343
dc.identifier.doi
10.3929/ethz-b-000225231
dc.description.abstract
Cutaneous wound healing is a complex process that aims to re-establish the original structure of the skin and its functions. Among other disorders, peripheral neuropathies are known to severely impair wound healing capabilities of the skin, revealing the importance of skin innervation for proper repair. Here, we report that peripheral glia are crucially involved in this process. Using a mouse model of wound healing, combined with in vivo fate mapping, we show that injury activates peripheral glia by promoting de-differentiation, cell-cycle re-entry and dissemination of the cells into the wound bed. Moreover, injury-activated glia upregulate the expression of many secreted factors previously associated with wound healing and promote myofibroblast differentiation by paracrine modulation of TGF-β signalling. Accordingly, depletion of these cells impairs epithelial proliferation and wound closure through contraction, while their expansion promotes myofibroblast formation. Thus, injury-activated glia and/or their secretome might have therapeutic potential in human wound healing disorders.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Injury-activated glial cells promote wound healing of the adult skin in mice
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2018-01-16
ethz.journal.title
Nature Communications
ethz.journal.volume
9
en_US
ethz.pages.start
236
en_US
ethz.size
16 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03520 - Werner, Sabine / Werner, Sabine
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03367 - Suter, Ulrich / Suter, Ulrich
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03520 - Werner, Sabine / Werner, Sabine
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03367 - Suter, Ulrich / Suter, Ulrich
ethz.date.deposited
2018-01-03T14:41:00Z
ethz.source
FORM
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-02-20T11:58:16Z
ethz.rosetta.lastUpdated
2019-02-02T14:54:10Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/225231
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/235641
ethz.COinS
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