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dc.contributor.author
Snedeker, Jess G.
dc.contributor.author
Foolen, Jasper
dc.date.accessioned
2018-02-20T15:07:33Z
dc.date.available
2017-11-23T06:32:48Z
dc.date.available
2018-01-30T15:48:02Z
dc.date.available
2018-01-30T22:24:59Z
dc.date.available
2018-02-20T15:07:33Z
dc.date.issued
2017-11
dc.identifier.issn
1742-7061
dc.identifier.issn
1878-7568
dc.identifier.other
10.1016/j.actbio.2017.08.032
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/242762
dc.identifier.doi
10.3929/ethz-b-000212506
dc.description.abstract
Tendon is an intricately organized connective tissue that efficiently transfers muscle force to the bony skeleton. Its structure, function, and physiology reflect the extreme, repetitive mechanical stresses that tendon tissues bear. These mechanical demands also lie beneath high clinical rates of tendon disorders, and present daunting challenges for clinical treatment of these ailments. This article aims to provide perspective on the most urgent frontiers of tendon research and therapeutic development. We start by broadly introducing essential elements of current understanding about tendon structure, function, physiology, damage, and repair. We then introduce and describe a novel paradigm explaining tendon disease progression from initial accumulation of damage in the tendon core to eventual vascular recruitment from the surrounding synovial tissues. We conclude with a perspective on the important role that biomaterials will play in translating research discoveries to the patient. Statement of Significance Tendon and ligament problems represent the most frequent musculoskeletal complaints for which patients seek medical attention. Current therapeutic options for addressing tendon disorders are often ineffective, and the need for improved understanding of tendon physiology is urgent. This perspective article summarizes essential elements of our current knowledge on tendon structure, function, physiology, damage, and repair. It also describes a novel framework to understand tendon physiology and pathophysiology that may be useful in pushing the field forward.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Tendon
en_US
dc.subject
Degeneration
en_US
dc.subject
Regeneration
en_US
dc.subject
Angiogenesis
en_US
dc.subject
Inflammation
en_US
dc.subject
Therapy
en_US
dc.title
Tendon injury and repair - A perspective on the basic mechanisms of tendon disease and future clinical therapy
en_US
dc.type
Review Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
dc.date.published
2017-09-01
ethz.journal.title
Acta Biomaterialia
ethz.journal.volume
63
en_US
ethz.pages.start
18
en_US
ethz.pages.end
36
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02518 - Institut für Biomechanik / Institute for Biomechanics::03822 - Snedeker, Jess G. / Snedeker, Jess G.
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02518 - Institut für Biomechanik / Institute for Biomechanics::03822 - Snedeker, Jess G. / Snedeker, Jess G.
ethz.date.deposited
2017-11-23T06:32:57Z
ethz.source
SCOPUS
ethz.source
BATCH
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-02-21T12:53:35Z
ethz.rosetta.lastUpdated
2018-11-06T11:14:19Z
ethz.rosetta.versionExported
true
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/237416
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/212506
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Tendon%20injury%20and%20repair%20-%20A%20perspective%20on%20the%20basic%20mechanisms%20of%20tendon%20disease%20and%20future%20clinical%20therapy&rft.jtitle=Acta%20Biomaterialia&rft.date=2017-11&rft.volume=63&rft.spage=18&rft.epage=36&rft.issn=1742-7061&1878-7568&rft.au=Snedeker,%20Jess%20G.&Foolen,%20Jasper&rft.genre=article&
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