Subregion-Specific Proteomic Signature in the Hippocampus for Recognition Processes in Adult Mice
von Ziegler, Lukas M.
Tweedie-Cullen, Ry Y.
Mansuy, Isabelle M.
- Journal Article
The hippocampal formation is a brain structure essential for higher-order cognitive functions. It has a complex anatomical organization and cellular composition, and hippocampal subregions have different properties and functional roles. In this study, we used SWATH-MS to determine whether the proteomes of hippocampus areas CA1 and CA3 can explain the commonalities or specificities of these subregions in basal conditions and after recognition memory. We show that the proteomes of areas CA1 and CA3 are largely different in basal conditions and that differential changes and dynamics in protein expression are induced in these areas after recognition of an object or object location. While changes are consistent across both recognition paradigms in area CA1, they are not in area CA3, suggesting distinct proteomic responses in areas CA1 and CA3 for memory formation. Show more
Journal / seriesCell Reports
Pages / Article No.
Organisational unit02207 - Functional Genomics Center Zürich / Functional Genomics Center Zürich
02207 - Functional Genomics Center Zürich / Functional Genomics Center Zürich
03518 - Mansuy, Isabelle / Mansuy, Isabelle
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