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dc.contributor.author
Emmenegger, Vishalini
dc.contributor.author
Qi, Guanxiao
dc.contributor.author
Wang, Haijun
dc.contributor.author
Feldmeyer, Dirk
dc.date.accessioned
2018-04-17T11:34:24Z
dc.date.available
2018-04-14T02:52:43Z
dc.date.available
2018-04-17T11:34:24Z
dc.date.issued
2018-04
dc.identifier.issn
1047-3211
dc.identifier.issn
1460-2199
dc.identifier.other
10.1093/cercor/bhx352
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/258130
dc.identifier.doi
10.3929/ethz-b-000258130
dc.description.abstract
GABAergic interneurons are notorious for their heterogeneity, despite constituting a small fraction of the neuronal population in the neocortex. Classification of interneurons is crucial for understanding their widespread cortical functions as they provide a complex and dynamic network, balancing excitation and inhibition. Here, we investigated different types of non-fast-spiking (nFS) interneurons in Layer 4 (L4) of rat barrel cortex using whole-cell patch-clamp recordings with biocytin-filling. Based on a quantitative analysis on a combination of morphological and electrophysiological parameters, we identified 5 distinct types of L4 nFS interneurons: 1) trans-columnar projecting interneurons, 2) locally projecting non-Martinotti-like interneurons, 3) supra-granular projecting Martinotti-like interneurons, 4) intra-columnar projecting VIP-like interneurons, and 5) locally projecting neurogliaform-like interneurons. Trans-columnar projecting interneurons are one of the most striking interneuron types, which have not been described so far in Layer 4. They feature extensive axonal collateralization not only in their home barrel but also in adjacent barrels. Furthermore, we identified that most of the L4 nFS interneurons express somatostatin, while few are positive for the transcription factor Prox1. The morphological and electrophysiological characterization of different L4 nFS interneuron types presented here provides insights into their synaptic connectivity and functional role in cortical information processing.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Oxford University Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc/4.0/
dc.subject
barrel cortex
en_US
dc.subject
GABAergic interneuron
en_US
dc.subject
Layer 4
en_US
dc.subject
non-fast spiking
en_US
dc.title
Morphological and Functional Characterization of Non-fast-Spiking GABAergic Interneurons in Layer 4 Microcircuitry of Rat Barrel Cortex
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial 4.0 International
dc.date.published
2018-01-10
ethz.journal.title
Cerebral Cortex
ethz.journal.volume
28
en_US
ethz.journal.issue
4
en_US
ethz.journal.abbreviated
Cereb. cortex
ethz.pages.start
1439
en_US
ethz.pages.end
1457
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2018-04-14T02:53:10Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-04-17T11:34:28Z
ethz.rosetta.lastUpdated
2018-12-02T09:42:54Z
ethz.rosetta.versionExported
true
ethz.COinS
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