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dc.contributor.author
Kut, Elvan
dc.contributor.author
Candia, Victor
dc.contributor.author
von Overbeck, Jan
dc.contributor.author
Pok, Judit
dc.contributor.author
Fink, Daniel
dc.contributor.author
Folkers, Gerd
dc.date.accessioned
2018-05-08T06:08:12Z
dc.date.available
2018-05-08T06:02:08Z
dc.date.available
2018-05-08T06:08:12Z
dc.date.issued
2011-03-16
dc.identifier.issn
0270-6474
dc.identifier.issn
1529-2401
dc.identifier.other
10.1523/JNEUROSCI.3736-10.2011
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/262807
dc.identifier.doi
10.3929/ethz-a-006783528
dc.description.abstract
Recent findings suggest that pain and pleasure share common neurochemical circuits, and studies in animals and humans show that opioid-mediated descending pathways can inhibit or facilitate pain. We explored the role of endogenous opioid neurotransmission in pleasure-related analgesia. μ-Opioidergic activity was blocked with 0.2 mg/kg naloxone to assess its effects on hedonic responses to pleasant emotional pictures (International Affective Picture System) and its modulating effects on heat pain tolerance. Naloxone did not alter subjective and autonomous reactions to pleasure induction or overall mood of participants. In addition, pleasure-related increases in pain tolerance persisted after reversal of endogenous μ-opioidergic neurotransmission. Subjective pain intensity and unpleasantness ratings increased after naloxone administration. These findings suggest that, in addition to opioid-sensitive circuits, mainly opioid-insensitive pain-modulating circuits are activated during pleasure-related analgesia.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Society for Neuroscience
en_US
dc.rights.uri
http://rightsstatements.org/page/InC-NC/1.0/
dc.title
Pleasure-Related Analgesia Activates Opioid-Insensitive Circuits
en_US
dc.type
Journal Article
dc.rights.license
In Copyright - Non-Commercial Use Permitted
ethz.journal.title
The Journal of Neuroscience
ethz.journal.volume
31
en_US
ethz.journal.issue
11
en_US
ethz.journal.abbreviated
J. Neurosci
ethz.pages.start
4148
en_US
ethz.pages.end
4153
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.publication.place
Washington, DC
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00003 - Schulleitung und Dienste::00030 - Bereich Rektorat / Domain Rectorate::02803 - Collegium Helveticum / Collegium Helveticum
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02045 - Dep. Geistes-, Sozial- u. Staatswiss. / Dep. of Humanities, Social and Pol.Sc.::03325 - Folkers, Gerd (emeritus)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00003 - Schulleitung und Dienste::00030 - Bereich Rektorat / Domain Rectorate::02803 - Collegium Helveticum / Collegium Helveticum
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02045 - Dep. Geistes-, Sozial- u. Staatswiss. / Dep. of Humanities, Social and Pol.Sc.::03325 - Folkers, Gerd (emeritus)
ethz.date.deposited
2017-06-09T17:13:08Z
ethz.source
ECOL
ethz.source
ECIT
ethz.identifier.importid
imp59366b168f5e075733
ethz.identifier.importid
imp59364ea2a61da74420
ethz.ecolpid
eth:4860
ethz.ecitpid
pub:68766
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-05-08T06:02:17Z
ethz.rosetta.lastUpdated
2020-02-15T12:49:39Z
ethz.rosetta.versionExported
true
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/153065
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/41126
ethz.COinS
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