The potential of CRISPR/Cas9 genome editing for the study and treatment of intervertebral disc pathologies
- Review Article
Rights / licenseCreative Commons Attribution 4.0 International
The CRISPR/Cas9 system has emerged as a powerful tool for mammalian genome engineering. In basic and translational intervertebral disc (IVD) research, this technique has remarkable potential to answer fundamental questions on pathway interactions, to simulate IVD pathologies, and to promote drug development. Furthermore, the precisely targeted CRISPR/Cas9 gene therapy holds promise for the effective and targeted treatment of degenerative disc disease and low back pain. In this perspective, we provide an overview of recent CRISPR/Cas9 advances stemming from/with transferability to IVD research, outline possible treatment approaches for degenerative disc disease, and discuss current limitations that may hinder clinical translation. Show more
Journal / seriesJOR Spine
Pages / Article No.
PublisherJohn Wiley & Sons Inc.
SubjectCRISPR/Cas9; Degenerative disc disease; Intervertebral disc; Low back pain; Targeted genome engineering
Organisational unit09597 - Würtz, Karin (SNF-Professur) (ehemalig) / Würtz, Karin (SNF-Professur) (former)
163678 - Unlocking the mechanisms of mechanotransduction in degenerative disc disease (TRIPDISC) (SNF)
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