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dc.contributor.author
Sajic, Tatjana
dc.contributor.author
Liu, Yansheng
dc.contributor.author
Arvaniti, Eirini
dc.contributor.author
Surinova, Silvia
dc.contributor.author
Williams, Evan G.
dc.contributor.author
Schiess, Ralph
dc.contributor.author
Hüttenhain, Ruth
dc.contributor.author
Sethi, Atul
dc.contributor.author
Pan, Sheng
dc.contributor.author
Brentnall, Teresa A.
dc.contributor.author
Chen, Ru
dc.contributor.author
Blattmann, Peter
dc.contributor.author
Friedrich, Betty
dc.contributor.author
Hüttenhain, Ruth
dc.contributor.author
Sethi, Atul
dc.contributor.author
Pan, Sheng
dc.contributor.author
Brentnall, Teresa A.
dc.contributor.author
Chen, Ru
dc.contributor.author
Blattmann, Peter
dc.contributor.author
Friedrich, Betty
dc.contributor.author
Niméus, Emma
dc.contributor.author
Malander, Susanne
dc.contributor.author
Omlin, Aurelius
dc.contributor.author
Gillessen, Silke
dc.contributor.author
Claassen, Manfred
dc.contributor.author
Aebersold, Ruedi
dc.date.accessioned
2018-06-18T13:44:43Z
dc.date.available
2018-06-08T06:56:15Z
dc.date.available
2018-06-18T13:44:43Z
dc.date.issued
2018-05-29
dc.identifier.other
10.1016/j.celrep.2018.04.114
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/268420
dc.identifier.doi
10.3929/ethz-b-000268420
dc.description.abstract
Cancer is mostly incurable when diagnosed at a metastatic stage, making its early detection via blood proteins of immense clinical interest. Proteomic changes in tumor tissue may lead to changes detectable in the protein composition of circulating blood plasma. Using a proteomic workflow combining N-glycosite enrichment and SWATH mass spectrometry, we generate a data resource of 284 blood samples derived from patients with different types of localized-stage carcinomas and from matched controls. We observe whether the changes in the patient’s plasma are specific to a particular carcinoma or represent a generic signature of proteins modified uniformly in a common, systemic response to many cancers. A quantitative comparison of the resulting N-glycosite profiles discovers that proteins related to blood platelets are common to several cancers (e.g., THBS1), whereas others are highly cancer-type specific. Available proteomics data, including a SWATH library to study N-glycoproteins, will facilitate follow-up biomarker research into early cancer detection.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
carcinoma
en_US
dc.subject
localized cancer
en_US
dc.subject
blood
en_US
dc.subject
glycoproteins
en_US
dc.subject
secreted
en_US
dc.subject
SWATH-mass spectrometry
en_US
dc.subject
human clinical study
en_US
dc.title
Similarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
ethz.journal.title
Cell Reports
ethz.journal.volume
23
en_US
ethz.journal.issue
9
en_US
ethz.pages.start
2819
en_US
ethz.pages.end
2831.e5
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03663 - Aebersold, Rudolf / Aebersold, Rudolf
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03984 - Claassen, Manfred / Claassen, Manfred
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03663 - Aebersold, Rudolf / Aebersold, Rudolf
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03984 - Claassen, Manfred / Claassen, Manfred
ethz.date.deposited
2018-06-08T06:56:32Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-06-18T13:44:56Z
ethz.rosetta.lastUpdated
2019-02-03T03:24:03Z
ethz.rosetta.versionExported
true
ethz.COinS
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