Neural signatures of Trail Making Test performance: Evidence from lesion-mapping and neuroimaging studies

Open access
Date
2018-07-01Type
- Journal Article
Citations
Cited 62 times in
Web of Science
Cited 70 times in
Scopus
ETH Bibliography
yes
Altmetrics
Abstract
The Trail Making Test (TMT) is an extensively used neuropsychological instrument for the assessment of set-switching ability across a wide range of neurological conditions. However, the exact nature of the cognitive processes and associated brain regions contributing to the performance on the TMT remains unclear. In this review, we first introduce the TMT by discussing its administration and scoring approaches. We then examine converging evidence and divergent findings concerning the brain regions related to TMT performance, as identified by lesion-symptom mapping studies conducted in brain-injured patients and functional magnetic resonance imaging studies conducted in healthy participants. After addressing factors that may account for the heterogeneity in the brain regions reported by these studies, we identify future research endeavours that may permit disentangling the different processes contributing to TMT performance and relating them to specific brain circuits. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000272818Publication status
publishedExternal links
Journal / series
NeuropsychologiaVolume
Pages / Article No.
Publisher
ElsevierSubject
TMT; Set-switching; fMRI; VLSM; Mental flexibilityMore
Show all metadata
Citations
Cited 62 times in
Web of Science
Cited 70 times in
Scopus
ETH Bibliography
yes
Altmetrics