Induction of Intracellular Reductive Stress with a Photoactivatable Phosphine Probe
dc.contributor.author
Tirla, Alina
dc.contributor.author
Rivera-Fuentes, Pablo
dc.date.accessioned
2018-07-18T10:08:20Z
dc.date.available
2018-07-18T02:36:03Z
dc.date.available
2018-07-18T10:08:20Z
dc.date.issued
2018-04
dc.identifier.issn
0009-4293
dc.identifier.other
10.2533/chimia.2018.241
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/276420
dc.identifier.doi
10.3929/ethz-b-000276420
dc.description.abstract
Reductive stress is a condition present in cells that have an increased concentration of reducing species, and it has been associated with a number of pathologies, such as neurodegenerative diseases and cancer. The tools available to study reductive stress lack both in selectivity and specific targeting and some of these shortcomings can be addressed by using photoactivatable compounds. We developed a photoactivatable phosphonium probe, which upon irradiation releases a fluorescent molecule and a trialkyphosphine. The probes can permeate through the plasma membrane and the photoreleased phosphine can induce intracellular reductive stress as proven by the detection of protein aggregates.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Swiss Chemical Society
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Photoactivation
en_US
dc.subject
Protein aggregation
en_US
dc.subject
Reductive stress
en_US
dc.subject
Tributylphosphine
en_US
dc.title
Induction of Intracellular Reductive Stress with a Photoactivatable Phosphine Probe
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
ethz.journal.title
Chimia
ethz.journal.volume
72
en_US
ethz.journal.issue
4
en_US
ethz.journal.abbreviated
Chimia
ethz.pages.start
241
en_US
ethz.pages.end
244
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Development of Intracellular Photoactivatable Probes
en_US
ethz.identifier.wos
ethz.publication.place
Bern
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02514 - Laboratorium für Organische Chemie / Laboratory of Organic Chemistry::09551 - Rivera Fuentes, Pablo M. (ehemalig) / Rivera Fuentes, Pablo M. (former)
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02514 - Laboratorium für Organische Chemie / Laboratory of Organic Chemistry::09551 - Rivera Fuentes, Pablo M. (ehemalig) / Rivera Fuentes, Pablo M. (former)
ethz.grant.agreementno
165551
ethz.grant.agreementno
165551
ethz.grant.agreementno
165551
ethz.grant.fundername
SNF
ethz.grant.fundername
SNF
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Projekte MINT
ethz.date.deposited
2018-07-18T02:36:45Z
ethz.source
WOS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-07-18T10:08:23Z
ethz.rosetta.lastUpdated
2022-03-28T20:40:51Z
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true
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