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dc.contributor.author
Meile, Lukas
dc.contributor.author
Croll, Daniel
dc.contributor.author
Brunner, Patrick C.
dc.contributor.author
Plissonneau, Clémence
dc.contributor.author
Hartmann, Fanny E.
dc.contributor.author
McDonald, Bruce A.
dc.contributor.author
Sánchez-Vallet, Andrea
dc.date.accessioned
2018-07-27T11:51:30Z
dc.date.available
2018-07-27T07:02:59Z
dc.date.available
2018-07-27T11:51:30Z
dc.date.issued
2018-08
dc.identifier.issn
0028-646X
dc.identifier.issn
1469-8137
dc.identifier.other
10.1111/nph.15180
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/278759
dc.identifier.doi
10.3929/ethz-b-000278759
dc.description.abstract
Cultivar‐strain specificity in the wheat–Zymoseptoria tritici pathosystem determines the infection outcome and is controlled by resistance genes on the host side, many of which have been identified. On the pathogen side, however, the molecular determinants of specificity remain largely unknown. We used genetic mapping, targeted gene disruption and allele swapping to characterise the recognition of the new avirulence factor Avr3D1. We then combined population genetic and comparative genomic analyses to characterise the evolutionary trajectory of Avr3D1. Avr3D1 is specifically recognised by wheat cultivars harbouring the Stb7 resistance gene, triggering a strong defence response without preventing pathogen infection and reproduction. Avr3D1 resides in a cluster of putative effector genes located in a genome region populated by independent transposable element insertions. The gene was present in all 132 investigated strains and is highly polymorphic, with 30 different protein variants identified. We demonstrated that specific amino acid substitutions in Avr3D1 led to evasion of recognition. These results demonstrate that quantitative resistance and gene‐for‐gene interactions are not mutually exclusive. Localising avirulence genes in highly plastic genomic regions probably facilitates accelerated evolution that enables escape from recognition by resistance proteins.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Wiley
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
avirulence factor
en_US
dc.subject
diversifying selection
en_US
dc.subject
evasion of recognition
en_US
dc.subject
gene‐for‐gene interactions
en_US
dc.subject
genome plasticity
en_US
dc.subject
plant pathogen
en_US
dc.subject
quantitative resistance
en_US
dc.subject
transposable elements
en_US
dc.title
A fungal avirulence factor encoded in a highly plastic genomic region triggers partial resistance to septoria tritici blotch
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2018-04-25
ethz.journal.title
New Phytologist
ethz.journal.volume
219
en_US
ethz.journal.issue
3
en_US
ethz.journal.abbreviated
New Phytol.
ethz.pages.start
1048
en_US
ethz.pages.end
1061
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Genomics of quantitative traits and chromosome instability in Zymoseptoria tritici
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03516 - McDonald, Bruce / McDonald, Bruce
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03516 - McDonald, Bruce / McDonald, Bruce
ethz.grant.agreementno
155955
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Projekte Lebenswissenschaften
ethz.date.deposited
2018-07-27T07:03:12Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-07-27T11:51:38Z
ethz.rosetta.lastUpdated
2022-03-28T20:46:40Z
ethz.rosetta.versionExported
true
ethz.COinS
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