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dc.contributor.author
Cingolani, Alberto
dc.contributor.author
Casalini, Tommaso
dc.contributor.author
Caimi, Stefano
dc.contributor.author
Klaue, Antoine
dc.contributor.author
Sponchioni, Mattia
dc.contributor.author
Rossi, Filippo
dc.contributor.author
Perale, Giuseppe
dc.date.accessioned
2018-08-07T13:39:52Z
dc.date.available
2018-08-02T07:31:40Z
dc.date.available
2018-08-07T13:39:52Z
dc.date.issued
2018-08
dc.identifier.other
10.3390/polym10080851
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/280003
dc.identifier.doi
10.3929/ethz-b-000280003
dc.description.abstract
In the last decades bioresorbable and biodegradable polymers have gained a very good reputation both in research and in industry thanks to their unique characteristics. They are able to ensure high performance and biocompatibility, at the same time avoiding post-healing surgical interventions for device removal. In the medical device industry, it is widely known that product formulation and manufacturing need to follow specific procedures in order to ensure both the proper mechanical properties and desired degradation profile. Moreover, the sterilization method is crucial and its impact on physical properties is generally underestimated. In this work we focused our attention on the effect of different terminal sterilization methods on two commercially available poly(l-lactide-co-ε-caprolactone) with equivalent chemical composition (70% PLA and 30% PCL) and relatively similar initial molecular weights, but different chain arrangements and crystallinity. Results obtained show that crystallinity plays a key role in helping preserve the narrow distribution of chains and, as a consequence, defined physical properties. These statements can be used as guidelines for a better choice of the most adequate biodegradable polymers in the production of resorbable medical devices.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
MDPI
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
electron beam
en_US
dc.subject
ethylene oxide
en_US
dc.subject
medical devices
en_US
dc.subject
polymers
en_US
dc.subject
sterilization
en_US
dc.title
A Methodologic Approach for the Selection of Bio-Resorbable Polymers in the Development of Medical Devices: The Case of Poly(l-lactide-co-ε-caprolactone)
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2018-08-01
ethz.journal.title
Polymers
ethz.journal.volume
10
en_US
ethz.journal.issue
8
en_US
ethz.pages.start
851
en_US
ethz.size
14 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Basel
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02516 - Inst. f. Chemie- und Bioingenieurwiss. / Inst. Chemical and Bioengineering::03451 - Morbidelli, Massimo (emeritus) / Morbidelli, Massimo (emeritus)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02516 - Inst. f. Chemie- und Bioingenieurwiss. / Inst. Chemical and Bioengineering::03451 - Morbidelli, Massimo (emeritus) / Morbidelli, Massimo (emeritus)
en_US
ethz.date.deposited
2018-08-02T07:31:42Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-08-07T13:39:59Z
ethz.rosetta.lastUpdated
2018-12-02T13:03:47Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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