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dc.contributor.author
Berry, Stewart
dc.contributor.author
Weinmann, Oliver
dc.contributor.author
Fritz, Ann-Kristina
dc.contributor.author
Rust, Ruslan
dc.contributor.author
Wolfer, David
dc.contributor.author
Schwab, Martin E.
dc.contributor.author
Gerber, Urs
dc.contributor.author
Ster, Jeanne
dc.date.accessioned
2018-08-07T08:00:57Z
dc.date.available
2018-08-02T07:45:03Z
dc.date.available
2018-08-07T08:00:57Z
dc.date.issued
2018
dc.identifier.issn
1932-6203
dc.identifier.other
10.1371/journal.pone.0200896
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/280018
dc.identifier.doi
10.3929/ethz-b-000280018
dc.description.abstract
Recent investigations of Nogo-A, a well characterized protein inhibitor of neurite outgrowth in the brain, have revealed additional functions including a role in neuropsychiatric disorders such as schizophrenia. Here we examined Nogo-A functions in mouse CA3 hippocampal circuitry. Patch clamp recordings showed that the absence of Nogo-A results in a hyperactive network. In addition, mGlu3 metabotropic glutamate receptors, which exhibit mutations in certain forms of schizophrenia, were downregulated specifically in the CA3 area. Furthermore, Nogo-A-/- mice showed disordered theta oscillations with decreased incidence and frequency, similar to those observed in mGlu3-/- mice. As disruptions in theta rhythmicity are associated with impaired spatial navigation, we tested mice using modified Morris water maze tasks. Mice lacking Nogo-A exhibited altered search strategies, displaying greater dependence on global as opposed to local reference frames. This link between Nogo-A and mGlu3 receptors may provide new insights into mechanisms underlying schizophrenia.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Loss of Nogo-A, encoded by the schizophrenia risk gene Rtn4, reduces mGlu3 expression and causes hyperexcitability in hippocampal CA3 circuits
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2018-07-24
ethz.journal.title
PLoS ONE
ethz.journal.volume
13
en_US
ethz.journal.issue
7
en_US
ethz.journal.abbreviated
PLoS ONE
ethz.pages.start
e0200896
en_US
ethz.size
22 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
San Francisco, CA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::03727 - Wolfer, David P. / Wolfer, David P.
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::03727 - Wolfer, David P. / Wolfer, David P.
ethz.date.deposited
2018-08-02T07:45:12Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-08-07T08:01:05Z
ethz.rosetta.lastUpdated
2019-02-03T05:05:38Z
ethz.rosetta.versionExported
true
ethz.COinS
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