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dc.contributor.author
Shirahata, Haruku
dc.contributor.author
Dakessian, Shant
dc.contributor.author
Hirao, Masahiko
dc.contributor.author
Sugiyama, Hirokazu
dc.contributor.editor
Eden, Mario R.
dc.contributor.editor
Ierapetritou, Marianthi G.
dc.contributor.editor
Towler, Gavin P.
dc.date.accessioned
2020-07-23T06:17:12Z
dc.date.available
2018-08-03T08:11:13Z
dc.date.available
2018-08-03T09:49:37Z
dc.date.available
2020-07-23T06:17:12Z
dc.date.issued
2018
dc.identifier.isbn
978-0-444-64243-1
en_US
dc.identifier.isbn
978-0-444-64241-7
en_US
dc.identifier.issn
1570-7946
dc.identifier.other
10.1016/B978-0-444-64241-7.50045-8
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/280228
dc.description.abstract
A platform is presented that enables systematic alternative generation and multiobjetive evaluation for designing biopharmaceutical drug product manufacturing processes. In the platform, the layers of product, unit operation, equipment technology, and operation are defined to assist generation of process alternatives as the combination of information at each layer. Multiple indicators are defined to evaluate economy, environment, supply, and product quality, which are aggregated to total score using weighting factors. A case study demonstrated that the developed platform can facilitate comprehensive process synthesis and multiobjective evaluation considering the novel disposable equipment technology for biopharmaceutical manufacturing known as single-use technology.
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.subject
Pharmaceuticals
en_US
dc.subject
Single-use technology
en_US
dc.subject
Process alternative generation
en_US
dc.subject
Multiobjective evaluation
en_US
dc.subject
Decision-making
en_US
dc.title
Multilayer and Multiobjective Design Platform for Drug Product Manufacturing Processes of Biopharmaceuticals
en_US
dc.type
Conference Paper
dc.date.published
2018-08-02
ethz.book.title
13th International Symposium on Process Systems Engineering (PSE 2018)
en_US
ethz.journal.title
Computer Aided Chemical Engineering
ethz.journal.volume
44
en_US
ethz.journal.issue
Part A
en_US
ethz.pages.start
301
en_US
ethz.pages.end
306
en_US
ethz.event
13th International Symposium on Process Systems Engineering (PSE 2018)
en_US
ethz.event.location
San Diego, CA, USA
en_US
ethz.event.date
July 1-5, 2018
en_US
ethz.identifier.scopus
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2018-08-03T08:11:26Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2018-08-03T09:49:40Z
ethz.rosetta.lastUpdated
2020-07-23T06:17:24Z
ethz.rosetta.versionExported
true
ethz.COinS
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