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dc.contributor.author
Erilova, Aleksandra
dc.contributor.author
Brownfield, Lynette
dc.contributor.author
Exner, Vivien
dc.contributor.author
Rosa, Marisa
dc.contributor.author
Twell, David
dc.contributor.author
Mittelsten Scheid, Ortrun
dc.contributor.author
Hennig, Lars
dc.contributor.author
Köhler, Claudia
dc.date.accessioned
2018-10-23T05:43:27Z
dc.date.available
2018-10-23T05:43:27Z
dc.date.issued
2009-09-25
dc.identifier.issn
1553-7390
dc.identifier.issn
1553-7404
dc.identifier.other
10.1371/journal.pgen.1000663
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/298000
dc.identifier.doi
10.3929/ethz-b-000019546
dc.description.abstract
Balanced maternal and paternal genome contributions are a requirement for successful seed development. Unbalanced contributions often cause seed abortion, a phenomenon that has been termed “triploid block.” Misregulation of imprinted regulatory genes has been proposed to be the underlying cause for abnormalities in growth and structure of the endosperm in seeds with deviating parental contributions. We identified a mutant forming unreduced pollen that enabled us to investigate direct effects of unbalanced parental genome contributions on seed development and to reveal the underlying molecular mechanism of dosage sensitivity. We provide evidence that parent-of-origin–specific expression of the Polycomb group (PcG) gene MEDEA is causally responsible for seed developmental aberrations in Arabidopsis seeds with increased paternal genome contributions. We propose that imprinted expression of PcG genes is an evolutionary conserved mechanism to balance parental genome contributions in embryo nourishing tissues.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Imprinting of the polycomb group gene MEDEA serves as a ploidy sensor in Arabidopsis
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
PLoS Genetics
ethz.journal.volume
5
en_US
ethz.journal.issue
9
en_US
ethz.journal.abbreviated
PLoS Genet
ethz.pages.start
e1000663
en_US
ethz.size
14 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
San Francisco, CA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02541 - Institut für Molekulare Pflanzenbiologie / Institute of Molecular Plant Biology::03554 - Gruissem, Wilhelm / Gruissem, Wilhelm
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02541 - Institut für Molekulare Pflanzenbiologie / Institute of Molecular Plant Biology::03554 - Gruissem, Wilhelm / Gruissem, Wilhelm
ethz.date.deposited
2017-06-08T23:37:32Z
ethz.source
ECIT
ethz.identifier.importid
imp59364ca6d933b86243
ethz.identifier.importid
imp59364cc5a31ac53552
ethz.ecitpid
pub:31898
ethz.ecitpid
pub:33761
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-10-23T05:43:32Z
ethz.rosetta.lastUpdated
2018-10-23T05:43:32Z
ethz.rosetta.versionExported
true
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/19546
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/162252
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Imprinting%20of%20the%20polycomb%20group%20gene%20MEDEA%20serves%20as%20a%20ploidy%20sensor%20in%20Arabidopsis&rft.jtitle=PLoS%20Genetics&rft.date=2009-09-25&rft.volume=5&rft.issue=9&rft.spage=e1000663&rft.issn=1553-7390&1553-7404&rft.au=Erilova,%20Aleksandra&Brownfield,%20Lynette&Exner,%20Vivien&Rosa,%20Marisa&Twell,%20David&rft.genre=article&
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