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An analytic and systematic framework for estimating metabolic flux ratios from ¹³C tracer experiments
(2008)BMC BioinformaticsBackground Metabolic fluxes provide invaluable insight on the integrated response of a cell to environmental stimuli or genetic modifications. Current computational methods for estimating the metabolic fluxes from 13C isotopomer measurement data rely either on manual derivation of analytic equations constraining the fluxes or on the numerical solution of a highly nonlinear system of isotopomer balance equations. In the first approach, ...Journal Article