Search
Results
-
Factors affecting farm growth intentions of family farms in mountain regions: Empirical evidence for Central Switzerland
(2015)Land Use PolicyJournal Article -
Field measurements of snowpack response to explosive loading
(2015)Cold Regions Science and TechnologyAvalanche control by explosives is among the key temporary preventive measures. Hitherto, little is known about wave propagation in a snowpack caused by an explosion. During the winter 2013–2014 we performed field experiments on a flat study site. We triggered slurry explosive charges at different heights above the snow surface. At three different distances from the point of explosion we measured surface air pressure and accelerations of ...Journal Article -
Three-dimensional mass density mapping of cellular ultrastructure by ptychographic X-ray nanotomography
(2015)Journal of Structural BiologyWe demonstrate absolute quantitative mass density mapping in three dimensions of frozen-hydrated biological matter with an isotropic resolution of 180 nm. As model for a biological system we use Chlamydomonas cells in buffer solution confined in a microcapillary. We use ptychographic X-ray computed tomography to image the entire specimen, including the 18 μm-diameter capillary, thereby providing directly an absolute mass density measurement ...Journal Article -
Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells
(2015)Cell ReportsRibosome biogenesis is a highly complex process requiring many assisting factors. Studies in yeast have yielded comprehensive knowledge of the cellular machinery involved in this process. However, many aspects of ribosome synthesis are different in higher eukaryotes, and the global set of mammalian ribosome biogenesis factors remains unexplored. We used an imaging-based, genome-wide RNAi screen to find human proteins involved in 40S ...Journal Article -
Controlling High-Latitude Southern Ocean Convection in Climate Models
(2015)Ocean ModellingJournal Article -
High-Resolution Profiling of Drosophila Replication Start Sites Reveals a DNA Shape and Chromatin Signature of Metazoan Origins
(2015)Cell ReportsAt every cell cycle, faithful inheritance of metazoan genomes requires the concerted activation of thousands of DNA replication origins. However, the genetic and chromatin features defining metazoan replication start sites remain largely unknown. Here, we delineate the origin repertoire of the Drosophila genome at high resolution. We address the role of origin-proximal G-quadruplexes and suggest that they transiently stall replication ...Journal Article -
Phylodynamic analysis of HIV sub-epidemics in Mochudi, Botswana
(2015)EpidemicsSouthern Africa continues to be the epicenter of the HIV/AIDS epidemic. This HIV-1 subtype C epidemic has a predominantly heterosexual mode of virus transmission and high (>15%) HIV prevalence among adults. The epidemiological dynamics of the HIV-1C epidemic in southern Africa are still poorly understood. Here, we aim at a better understanding of HIV transmission dynamics by analyzing HIV-1 subtype C sequences from Mochudi, a peri-urban ...Journal Article -
Tectonic and lithological controls on denudation rates in the central Bolivian Andes
(2015)TectonophysicsThe topographic signature of a mountain belt depends on the interplay of tectonic, climatic and erosional processes, whose relative importance changes over times, while quantifying these processes and their rates at specific times remains a challenge. The eastern Andes of central Bolivia offer a natural laboratory in which such interplay has been debated. Here, we investigate the Rio Grande catchment which crosses orthogonally the eastern ...Journal Article -
Assessment of soil moisture effects on L-band radar interferometry
(2015)Remote Sensing of EnvironmentDifferential SAR interferometry, a popular technique for measuring displacements of the Earth's surface, is potentially influenced by changes in soil moisture. Different mechanisms for this impact have been proposed, but its magnitude, sign and even presence remain poorly understood. In this study the dependence of the phase, the coherence magnitude as well as the phase triplets on soil moisture was inferred empirically with regression ...Journal Article -
Estimating the building based energy consumption as an anthropogenic contribution to urban heat islands
(2015)Sustainable Cities and SocietyToday the implication of buildings’ electricity demand on the outdoor climate around buildings is not fully understood. For tropical cities like Singapore, where air-conditioning is required throughout the year and high rise buildings irregularly alternate with lower buildings, the distribution of this so called anthropogenic heat emissions in time and space is determining the local and overall contribution to the urban heat island ...Journal Article