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Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury
(2015)Cell ReportsDemyelinating diseases are characterized by a loss of oligodendrocytes leading to axonal degeneration and impaired brain function. Current strategies used for the treatment of demyelinating disease such as multiple sclerosis largely rely on modulation of the immune system. Only limited treatment options are available for treating the later stages of the disease, and these treatments require regenerative therapies to ameliorate the ...Journal Article -
Flexible weather index-based insurance design
(2015)Climate Risk ManagementThis study investigates the performance of a flexible index design for weather index-based insurances using farm-level panel data on wheat production from Kazakhstan. The proposed flexible design is a generic framework that uses Growing Degree Days to determine annual variable start and end dates for the insured period. This approach reflects the progress of phenological plant growth phases more accurately than fixed periods and hence is ...Journal Article -
Thrombus formation in the left ventricle after large myocardial infarction - assessment with cardiac magnetic resonance imaging
(2015)Swiss Medical WeeklyINTRODUCTION: Left ventricular thrombus (LVT) formation may worsen the post-infarct outcome as a result of thromboembolic events. It also complicates the use of modern antiplatelet regimens, which are not compatible with long-term oral anticoagulation. The knowledge of the incidence of LVT may therefore be of importance to guide antiplatelet and antithrombotic therapy after acute myocardial infarction (AMI). METHODS: In 177 patients ...Journal Article -
Single-Stranded DNA-Binding Transcriptional Regulator FUBP1 Is Essential for Fetal and Adult Hematopoietic Stem Cell Self-Renewal
(2015)Cell ReportsThe ability of hematopoietic stem cells (HSCs) to self-renew is a prerequisite for the establishment of definitive hematopoiesis and life-long blood regeneration. Here, we report the single-stranded DNA-binding transcriptional regulator far upstream element (FUSE)-binding protein 1 (FUBP1) as an essential factor of HSC self-renewal. Functional inactivation of FUBP1 in two different mouse models resulted in embryonic lethal anemia at around ...Journal Article -
The Salivary Gland Acts as a Sink for Tissue-Resident Memory CD8+ T Cells, Facilitating Protection from Local Cytomegalovirus Infection
(2015)Cell ReportsTissue-resident memory T cells (TRM) reside in barrier tissues and provide local immediate protective immunity. Here, we show that the salivary gland (SG) most-effectively induces CD8+ and CD4+ TRM cells against murine cytomegalovirus (MCMV), which persists in and spreads from this organ. TRM generation depended on local antigen for CD4+, but not CD8+, TRM cells, highlighting major differences in T cell subset-specific demands for TRM ...Journal Article -
Highly sensitive, non-invasive detection of colorectal cancer mutations using single molecule, third generation sequencing
(2015)Applied and Translational GenomicsColorectal cancer (CRC) represents one of the most prevalent and lethal malignant neoplasms and every individual of age 50 and above should undergo regular CRC screening. Currently, the most effective preventive screening procedure to detect adenomatous polyps, the precursors to CRC, is colonoscopy. Since every colorectal cancer starts as a polyp, detecting all polyps and removing them is crucial. By exactly doing that, colonoscopy reduces ...Journal Article -
Weak versus strong knowledge interdependence: A comparison of two rationales for distributing information among learners in collaborative learning settings
(2015)Learning and InstructionJournal Article -
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A versatile bioink for three-dimensional printing of cellular scaffolds based on thermally and photo-triggered tandem gelation
(2015)Acta BiomaterialiaJournal Article -
Altered emotionality and neuronal excitability in mice lacking KCTD12, an auxiliary subunit of GABA(B) receptors associated with mood disorders
(2015)Translational PsychiatryGamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, is fundamental to brain function andimplicated in the pathophysiology of several neuropsychiatric disorders. GABA activates G-protein-coupled GABABreceptorscomprising principal GABAB1and GABAB2subunits as well as auxiliary KCTD8, 12, 12b and 16 subunits. TheKCTD12gene has beenassociated with bipolar disorder, major depressive disorder and schizophrenia. ...Journal Article