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Silander, Olin K.
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Rights / licenseCreative Commons Attribution 2.0 Generic
Background. Orthologous genes are frequently presumed to perform similar functions. However, outside of model organisms, this is rarely tested. One means of inferring changes in function is if there are changes in the level of gene conservation and selective constraint. Here we compare levels of gene conservation across three bacterial groups to test for changes in gene functionality. Findings. The level of gene conservation for different orthologous genes is highly correlated across clades, even for highly divergent groups of bacteria. These correlations do not arise from broad differences in gene functionality (e.g. informational genes vs. metabolic genes), but instead seem to result from very specific differences in gene function. Furthermore, these functional differences appear to be maintained over very long periods of time. Conclusion. These results suggest that even over broad time scales, most bacterial genes are under a nearly constant level of purifying selection, and that bacterial evolution is thus dominated by selective and functional stasis Show more
Journal / seriesBMC Research Notes
Pages / Article No.
SubjectMIKROBIELLE GENETIK (MIKROBIOLOGIE); STRUKTUR UND FUNKTION VON GENEN (GENETIK); EVOLUTION (BIOLOGIE); VERERBUNG UND VARIATION ALS EVOLUTIONSFAKTOREN (BIOLOGISCHE EVOLUTION); MICROBIAL GENETICS (MICROBIOLOGY); STRUCTURE AND FUNCTION OF GENES (GENETICS); EVOLUTION (BIOLOGY); HEREDITY AND VARIATION AS EVOLUTIONARY FACTORS (BIOLOGICAL EVOLUTION); Orthologous Gene; Growth Yield; Gene Essentiality; Functional Importance; Bacterial Group
Organisational unit02720 - Institut für Integrative Biologie / Institute of Integrative Biology
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