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dc.contributor.author
Silander, Olin K.
dc.contributor.author
Ackermann, Martin
dc.date.accessioned
2019-06-20T13:02:05Z
dc.date.available
2018-10-31T15:00:05Z
dc.date.available
2019-06-20T12:58:40Z
dc.date.available
2019-06-20T13:02:05Z
dc.date.issued
2009
dc.identifier.issn
1756-0500
dc.identifier.other
10.1186/1756-0500-2-2
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/300253
dc.identifier.doi
10.3929/ethz-a-005751946
dc.description.abstract
Background. Orthologous genes are frequently presumed to perform similar functions. However, outside of model organisms, this is rarely tested. One means of inferring changes in function is if there are changes in the level of gene conservation and selective constraint. Here we compare levels of gene conservation across three bacterial groups to test for changes in gene functionality. Findings. The level of gene conservation for different orthologous genes is highly correlated across clades, even for highly divergent groups of bacteria. These correlations do not arise from broad differences in gene functionality (e.g. informational genes vs. metabolic genes), but instead seem to result from very specific differences in gene function. Furthermore, these functional differences appear to be maintained over very long periods of time. Conclusion. These results suggest that even over broad time scales, most bacterial genes are under a nearly constant level of purifying selection, and that bacterial evolution is thus dominated by selective and functional stasis.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Biomed Central
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/2.0/
dc.subject
MIKROBIELLE GENETIK (MIKROBIOLOGIE)
en_US
dc.subject
STRUKTUR UND FUNKTION VON GENEN (GENETIK)
en_US
dc.subject
EVOLUTION (BIOLOGIE)
en_US
dc.subject
VERERBUNG UND VARIATION ALS EVOLUTIONSFAKTOREN (BIOLOGISCHE EVOLUTION)
en_US
dc.subject
MICROBIAL GENETICS (MICROBIOLOGY)
en_US
dc.subject
STRUCTURE AND FUNCTION OF GENES (GENETICS)
en_US
dc.subject
EVOLUTION (BIOLOGY)
en_US
dc.subject
HEREDITY AND VARIATION AS EVOLUTIONARY FACTORS (BIOLOGICAL EVOLUTION)
en_US
dc.subject
Orthologous Gene
en_US
dc.subject
Growth Yield
en_US
dc.subject
Gene Essentiality
en_US
dc.subject
Functional Importance
en_US
dc.subject
Bacterial Group
en_US
dc.title
The constancy of gene conservation across divergent bacterial orders
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 2.0 Generic
dc.date.published
2009-01-07
ethz.journal.title
BMC Research Notes
ethz.journal.volume
2
en_US
ethz.journal.issue
1
en_US
ethz.size
9 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.code.ddc
5 - Science::570 - Life sciences
en_US
ethz.identifier.nebis
005561181
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology
en_US
ethz.date.deposited
2017-06-13T07:57:59Z
ethz.source
ECOL
ethz.source
ECIT
ethz.identifier.importid
imp59366acdabfa315793
ethz.identifier.importid
imp59364ce77e04f57600
ethz.ecolpid
eth:41382
ethz.ecitpid
pub:35762
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-10-31T15:00:28Z
ethz.rosetta.lastUpdated
2019-06-20T13:02:18Z
ethz.rosetta.exportRequired
false
ethz.rosetta.versionExported
true
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/150965
dc.identifier.olduri
http://hdl.handle.net/20.500.11850/157423
ethz.COinS
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