Zur Kurzanzeige

dc.contributor.author
Van De Ven, Liesbeth I.
dc.contributor.author
Klop, Corinne
dc.contributor.author
Overbeek, Jetty A.
dc.contributor.author
de Vries, Frank
dc.contributor.author
Burden, Andrea
dc.contributor.author
Janssen, Paddy K.
dc.date.accessioned
2018-11-23T10:35:40Z
dc.date.available
2018-11-05T14:45:09Z
dc.date.available
2018-11-23T10:35:40Z
dc.date.issued
2018-11
dc.identifier.issn
0937-941X
dc.identifier.issn
1433-2965
dc.identifier.issn
0936-6555
dc.identifier.other
10.1007/s00198-018-4632-4
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/301136
dc.identifier.doi
10.3929/ethz-b-000301136
dc.description.abstract
Summary This is the first study to examine the association between antidepressant and benzodiazepine use following a MOF and risk of subsequent fracture in those 65+. Using national data, drug use following MOF showed that the 1-year fully adjusted risk of subsequent MOF in those on antidepressants was more than doubled. Introduction We evaluated the association between the use of antidepressants or benzodiazepines and the risk of a subsequent major osteoporotic fracture. Methods A cohort study was performed using the Dutch PHARMO Database Network. Between 2002 and 2011, a total of 4854 patients sustained a first major osteoporotic fracture after the age of 65 years, of which 1766 sustained a hip fracture. Incidence rates and adjusted hazard ratios were calculated using Cox proportional hazards models. Results Within 1 year following a major osteoporotic fracture, 15% (95% CI 13.7–15.7) and 31% (95% CI 30.1–32.8) of patients were dispensed an antidepressant or benzodiazepine, respectively. Current use of antidepressants in the first year following a major osteoporotic fracture was associated with subsequent fracture (adjusted HR 2.17 (95% CI 1.37–3.43)). Recent and past use of antidepressants were also associated with an increased risk of subsequent fracture. When the complete follow-up period was included, only the current use of antidepressants was associated with subsequent fracture following a major osteoporotic fracture (adjusted HR 1.48; 95% CI 1.06–2.06). Current benzodiazepine use was not associated with an increased risk of fracture within 1 year following a major osteoporotic fracture (adjusted HR 1.18; 95% CI 0.76–1.81) or during the complete follow-up period (adjusted HR 1.18; 95% CI 0.90–1.55). Conclusion This study provides evidence that antidepressants should be used with caution following a major osteoporotic fracture. It provides needed insights that can be used to inform clinicians when assessing subsequent fracture risk in patients.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Springer
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc/4.0/
dc.subject
Antidepressants
en_US
dc.subject
Benzodiazepines
en_US
dc.subject
Hip fracture
en_US
dc.subject
Major osteoporotic fracture
en_US
dc.subject
Subsequent fracture
en_US
dc.title
Association between use of antidepressants or benzodiazepines and the risk of subsequent fracture among those aged 65+ in the Netherlands
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial 4.0 International
dc.date.published
2018-08-15
ethz.journal.title
Osteoporosis International
ethz.journal.volume
29
en_US
ethz.journal.issue
11
en_US
ethz.journal.abbreviated
Osteoporos. int.
ethz.pages.start
2477
en_US
ethz.pages.end
2485
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::09633 - Burden, Andrea / Burden, Andrea
en_US
ethz.date.deposited
2018-11-05T14:45:16Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2018-11-23T10:35:56Z
ethz.rosetta.lastUpdated
2019-01-03T09:40:02Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Association%20between%20use%20of%20antidepressants%20or%20benzodiazepines%20and%20the%20risk%20of%20subsequent%20fracture%20among%20those%20aged%2065+%20in%20the%20Nethe&rft.jtitle=Osteoporosis%20International&rft.date=2018-11&rft.volume=29&rft.issue=11&rft.spage=2477&rft.epage=2485&rft.issn=0937-941X&1433-2965&0936-6555&rft.au=Van%20De%20Ven,%20Liesbeth%20I.&Klop,%20Corinne&Overbeek,%20Jetty%20A.&de%20Vries,%20Frank&Burden,%20Andrea&rft.genre=article&
 Suchen via SFX

Dateien zu diesem Eintrag

Thumbnail

Publikationstyp

Zur Kurzanzeige